Pentoxifylline Neuroprotective Effects Are Possibly Related to Its Anti-Inflammatory and TNF-Alpha Inhibitory Properties, in the 6-OHDA Model of Parkinson’s Disease

Figure 1

Pentoxifylline treatments (PTX: 10, 25, and 50 mg/kg, 15 days) decrease the apomorphine-induced rotational behavior in the 6-OHDA group, relatively to the untreated 6-OHDA group. The values are means ± SEM from 8 to 11 animals per group. A versus SO, q = 12.66 ; B versus 6-OHDA + PTX10, q = 7.211 ; C versus 6-OHDA + PTX25, q = 8.790 ; D versus 6-OHDA + PTX50, q = 10.14 ; E versus SO, q = 4.726 ; F versus SO, q = 4.169 .  , (one-way ANOVA and Newman-Keuls as the post hoc test).