Pentoxifylline Neuroprotective Effects Are Possibly Related to Its Anti-Inflammatory and TNF-Alpha Inhibitory Properties, in the 6-OHDA Model of Parkinson’s Disease

Figure 10

Representative photomicrographs from striata showing that PTX treatments decrease the immunostaining for COX-2 of 6-OHDA-lesioned rats. A similar profile was seen for iNOS immunostaining in the ipsilateral striatum of 6-OHDA-lesioned rats, after PTX treatments. COX-2: A versus SO, q = 9.529 ; B versus 6-OHDA + PTX25, q = 4.319 ; C versus 6-OHDA + PTX50, q = 5.192 ; D versus SO, q = 7.932 ; E versus SO, q = 4.766 ; F versus SO, q = 3.894 ; G versus 6-OHDA + PTX10, q = 3.669 . iNOS: A versus SO, q = 21.92 ; B versus 6-OHDA + PTX25, q = 5.208 ; C versus 6-OHDA + PTX50, q = 15.73 ; D versus SO, q = 16.71 ; E versus SO, q = 6.193 ; F versus 6-OHDA + PTX50, q = 10.52 (one-way ANOVA and Newman-Keuls as the post hoc test).

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