Pentoxifylline Neuroprotective Effects Are Possibly Related to Its Anti-Inflammatory and TNF-Alpha Inhibitory Properties, in the 6-OHDA Model of Parkinson’s Disease

Figure 2

Pentoxifylline treatments (PTX: 10, 25, and 50 mg/kg, 15 days) reverse behavioral alterations in the 6-OHDA group, relatively to untreated 6-OHDA rats, as assessed by the open field test. The values are means ± SEM from 9 to 20 animals per group. (a) Number of crossings/5 min (locomotor activity): A versus SO, ; B versus 6-OHDA, ; C versus 6-OHDA, ; D versus 6-OHDA, . (b) Number of rearing movements/5 min (vertical exploratory activity): A versus SO, ; B versus SO, ; C versus SO, ; D versus 6-OHDA, (two-tailed Student’s t-test).

(a)

(b)