Research Article
Altered Brain Activation in Early Drug-Naive Parkinson’s Disease during Heat Pain Stimuli: An fMRI Study
Table 1
Demographics, clinical characteristics, and sensory thresholds.
| | | PD () | CON () | value | | | Means ± SD | Means ± SD |
| | Age (years) | 62.79 ± 4.59 | 61.35 ± 4.27 | 0.376 | | Gender* | 11 M/3 F | 13 M/4 F | 0.889 | | Disease duration (years) | 2.46 ± 1.43 | — | — | | UPDRS score | | | | | Part I—mood/cognition | 2.93 ± 1.14 | — | — | | Part II—activities of daily living | 9.93 ± 2.27 | — | — | | Part III—motor examination | 21.79 ± 5.66 | — | — | | Part IV—complications of therapy | 0 | — | — | | MMSE score | 23.93 ± 2.13 | — | — | | VAS | 4.77 ± 1.30 | 5.69 ± 1.25 | 0.064 | | WST | 37.01 ± 1.44 | 35.74 ± 1.39 | 0.022 | | HPT | 47.74 ± 2.09 | 45.33 ± 3.44 | 0.042 |
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Note: *Chi-square test.
M, male; F, female; UPDRS, unified Parkinson’s disease rating scale; MMSE, mini-mental state exam; VAS, visual analog scale; WST, warm sense thresholds; HPT, heat-induced pain thresholds.
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