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Parkinson’s Disease
Volume 2015, Article ID 348063, 6 pages
http://dx.doi.org/10.1155/2015/348063
Research Article

Rapid Screening for Cognitive Impairment in Parkinson’s Disease: A Pilot Study

1Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, BLK MD3 Level 4 #04-01, 16 Medical Drive, Singapore 117600
2Department of Medicine, Yong Loo Lin School of Medicine, National University Health System, 1E, Level 10, NUHS Tower Block, Kent Ridge Road, Singapore 119228
3CHeBA, NPI, Euroa Centre, Prince of Wales Hospital, Barker Street, Randwick, NSW 2031, Australia
4Division of Neurology, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074

Received 22 October 2015; Revised 18 November 2015; Accepted 18 November 2015

Academic Editor: Hélio Teive

Copyright © 2015 YanHong Dong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. This study sought to establish the discriminant validity of a rapid cognitive screen, that is, the National Institute of Neurological Disease and Stroke-Canadian Stroke Network (NINDS-CSN) 5-minute protocol, and compare its discriminant validity to the Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE) in detecting cognitive impairment (CI) in PD patients. Methods. One hundred and one PD patients were recruited from a movement disorders clinic in Singapore and they received the NINDS-CSN 5-minute protocol, MoCA, and MMSE. No cognitive impairment (NCI) was defined as Clinical Dementia Rating (CDR) = 0 and CI was defined as CDR ≥ 0.5. Results. Area under the receiver operating characteristic curve of NINDS-CSN 5-minute protocol was statistically equivalent to MoCA and larger than MMSE (0.86 versus 0.90, ; 0.86 versus 0.76, ). The sensitivity of NINDS-CSN 5-minute protocol (<9) was statistically equivalent to MoCA (<22) (0.77 versus 0.85, ) and superior to MMSE (<24) (0.77 versus 0.52, ) in detecting CI, while the specificity of NINDS-CSN 5-minute protocol (<9) was statistically equivalent to MoCA (<22) and MMSE (<24) (0.78 versus 0.88, ). Conclusion. The NINDS-CSN 5-minute protocol is time expeditious while remaining statistically equivalent to MoCA and superior to MMSE and therefore is suitable for rapid cognitive screening of CI in PD patients.