Progesterone Exerts a Neuromodulatory Effect on Turning Behavior of Hemiparkinsonian Male Rats: Expression of 3<b><i>α</i></b>-Hydroxysteroid Oxidoreductase and Allopregnanolone as Suggestive of <svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" style="vertical-align:-4.374pt" id="M1" height="16.4128pt" version="1.1" viewBox="-0.0657574 -12.0388 57.6693 16.4128" width="57.6693pt"><g transform="matrix(.018,0,0,-0.018,0,0)"><path id="g190-72" d="M692 302H438V274C537 267 543 260 543 188V103C543 61 531 48 511 37C489 26 458 20 424 20C231 20 146 188 146 333C146 517 258 630 411 630C507 630 582 597 606 474L634 480C627 546 622 601 619 636C586 643 510 665 426 665C230 665 44 552 44 321C44 122 191 -15 411 -15C491 -15 573 7 635 21C629 49 628 81 628 116V202C628 261 632 266 692 274V302Z"/></g><g transform="matrix(.018,0,0,-0.018,12.787,0)"><path id="g190-66" d="M673 0V28C608 34 594 43 563 129C499 303 432 494 370 665L339 656L132 132C98 43 84 37 20 28V0H238V28C162 35 154 45 175 108C188 150 203 192 219 237H432C454 176 474 122 487 83S491 36 428 28V0H673ZM418 280H234C265 362 296 450 328 535H330L418 280Z"/></g><g transform="matrix(.018,0,0,-0.018,25.145,0)"><path id="g190-67" d="M372 352C427 368 507 407 507 502C507 548 486 592 451 616C420 638 376 650 301 650H44V622C124 616 128 610 128 527V123C128 40 122 34 36 28V0H257C336 0 402 12 453 40C512 72 548 124 548 191C548 291 471 335 372 350V352ZM213 362V558C213 591 216 602 226 608C235 614 258 618 282 618C377 618 415 558 415 490C415 406 369 362 260 362H213ZM213 328H258C380 328 450 283 450 181C450 76 377 35 296 34C231 34 213 53 213 125V328Z"/></g><g transform="matrix(.018,0,0,-0.018,35.793,0)"><use xlink:href="#g190-66"/></g><g transform="matrix(.013,0,0,-0.013,48.197,4.308)"><use xlink:href="#g190-66"/></g></svg> Receptors Involvement

<table class="figure-group"><tr class="fig-image" id="a"><td><object data="https://static.hindawi.com/articles/pd/volume-2015/431690/figures/431690.fig.002a.svgz" name="431690.fig.002a" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(a) </b>Experimental procedure I</td></tr><tr class="fig-image" id="b"><td><object data="https://static.hindawi.com/articles/pd/volume-2015/431690/figures/431690.fig.002b.svgz" name="431690.fig.002b" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(b) </b>Experimental procedure II</td></tr></table>

<div>(a) Experimental procedure I: performed to evaluate the effects of progesterone on turning behavior and effects on nigrostriatal expression and enzymatic activity of 3<i>α</i>-HSOR of hemiparkinsonian rats. (b) Experimental procedure II: performed to study the effects of allopregnanolone on turning behavior of hemiparkinsonian rats. HP group (hemiparkinsonian group), P<sub>4</sub>-treated HP group (progesterone-treated hemiparkinsonian group). Time 0: surgery-day.</div>

Parkinson’s Disease

fig2

Figure 2

Figure 2: Progesterone Exerts a Neuromodulatory Effect on Turning Behavior of Hemiparkinsonian Male Rats: Expression of 3<b><i>α</i></b>-Hydroxysteroid Oxidoreductase and Allopregnanolone as Suggestive of <svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" style="vertical-align:-4.374pt" id="M1" height="16.4128pt" version="1.1" viewBox="-0.0657574 -12.0388 57.6693 16.4128" width="57.6693pt"><g transform="matrix(.018,0,0,-0.018,0,0)"><path id="g190-72" d="M692 302H438V274C537 267 543 260 543 188V103C543 61 531 48 511 37C489 26 458 20 424 20C231 20 146 188 146 333C146 517 258 630 411 630C507 630 582 597 606 474L634 480C627 546 622 601 619 636C586 643 510 665 426 665C230 665 44 552 44 321C44 122 191 -15 411 -15C491 -15 573 7 635 21C629 49 628 81 628 116V202C628 261 632 266 692 274V302Z"/></g><g transform="matrix(.018,0,0,-0.018,12.787,0)"><path id="g190-66" d="M673 0V28C608 34 594 43 563 129C499 303 432 494 370 665L339 656L132 132C98 43 84 37 20 28V0H238V28C162 35 154 45 175 108C188 150 203 192 219 237H432C454 176 474 122 487 83S491 36 428 28V0H673ZM418 280H234C265 362 296 450 328 535H330L418 280Z"/></g><g transform="matrix(.018,0,0,-0.018,25.145,0)"><path id="g190-67" d="M372 352C427 368 507 407 507 502C507 548 486 592 451 616C420 638 376 650 301 650H44V622C124 616 128 610 128 527V123C128 40 122 34 36 28V0H257C336 0 402 12 453 40C512 72 548 124 548 191C548 291 471 335 372 350V352ZM213 362V558C213 591 216 602 226 608C235 614 258 618 282 618C377 618 415 558 415 490C415 406 369 362 260 362H213ZM213 328H258C380 328 450 283 450 181C450 76 377 35 296 34C231 34 213 53 213 125V328Z"/></g><g transform="matrix(.018,0,0,-0.018,35.793,0)"><use xlink:href="#g190-66"/></g><g transform="matrix(.013,0,0,-0.013,48.197,4.308)"><use xlink:href="#g190-66"/></g></svg> Receptors Involvement 

Figure 2 | Progesterone Exerts a Neuromodulatory Effect on Turning Behavior of Hemiparkinsonian Male Rats: Expression of 3α-Hydroxysteroid Oxidoreductase and Allopregnanolone as Suggestive of  Receptors Involvement 