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Parkinson’s Disease
Volume 2015, Article ID 431690, 9 pages
http://dx.doi.org/10.1155/2015/431690
Research Article

Progesterone Exerts a Neuromodulatory Effect on Turning Behavior of Hemiparkinsonian Male Rats: Expression of 3α-Hydroxysteroid Oxidoreductase and Allopregnanolone as Suggestive of Receptors Involvement

1Instituto de Investigaciones Biomédicas (INBIOMED)-IMBECU-CONICET, Universidad de Mendoza, Huarpes 698, 5500 Mendoza, Argentina
2Área de Farmacología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Avenida Libertador 80, Centro Universitario, 5500 Mendoza, Argentina

Received 18 December 2014; Accepted 12 March 2015

Academic Editor: Dianbo Qu

Copyright © 2015 Roberto Yunes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. W. Dauer and S. Przedborski, “Parkinson's disease: mechanisms and models,” Neuron, vol. 39, no. 6, pp. 889–909, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. M. W. Hayes, V. S. Fung, T. E. Kimber, and J. D. O'Sullivan, “Current concepts in the management of Parkinson disease,” Medical Journal of Australia, vol. 192, no. 3, pp. 144–149, 2010. View at Google Scholar · View at Scopus
  3. R. Deumens, A. Blokland, and J. Prickaerts, “Modeling Parkinson's disease in rats: an evaluation of 6-OHDA lesions of the nigrostriatal pathway,” Experimental Neurology, vol. 175, no. 2, pp. 303–317, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Galvan and T. Wichmann, “Pathophysiology of Parkinsonism,” Clinical Neurophysiology, vol. 119, no. 7, pp. 1459–1474, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. L. M. Shulman and V. Bhat, “Gender disparities in Parkinson's disease,” Expert Review of Neurotherapeutics, vol. 6, no. 3, pp. 407–416, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Bourque, D. E. Dluzen, and T. Di Paolo, “Neuroprotective actions of sex steroids in Parkinson's disease,” Frontiers in Neuroendocrinology, vol. 30, no. 2, pp. 142–157, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Chen, J. Nilsen, and R. D. Brinton, “Dose and temporal pattern of estrogen exposure determines neuroprotective outcome in hippocampal neurons: therapeutic implications,” Endocrinology, vol. 147, no. 11, pp. 5303–5313, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. R. D. Brinton, R. F. Thompson, M. R. Foy et al., “Progesterone receptors: form and function in brain,” Frontiers in Neuroendocrinology, vol. 29, no. 2, pp. 313–339, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. C. A. Frye, “Progestins influence motivation, reward, conditioning, stress, and/or response to drugs of abuse,” Pharmacology Biochemistry and Behavior, vol. 86, no. 2, pp. 209–219, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. J. M. Wang, L. Liu, R. W. Irwin, S. Chen, and R. D. Brinton, “Regenerative potential of allopregnanolone,” Brain Research Reviews, vol. 57, no. 2, pp. 398–409, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. P. Zheng, “Neuroactive steroid regulation of neurotransmitter release in the CNS: action, mechanism and possible significance,” Progress in Neurobiology, vol. 89, no. 2, pp. 134–152, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. F. A. Giuliani, R. Yunes, C. E. Mohn, M. Laconi, V. Rettori, and R. Cabrera, “Allopregnanolone induces LHRH and glutamate release through NMDA receptor modulation,” Endocrine, vol. 40, no. 1, pp. 21–26, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Guennoun, F. Labombarda, M. C. G. Deniselle, P. Liere, A. F. De Nicola, and M. Schumacher, “Progesterone and allopregnanolone in the central nervous system: response to injury and implication for neuroprotection,” The Journal of Steroid Biochemistry and Molecular Biology, vol. 146, pp. 48–61, 2015. View at Publisher · View at Google Scholar
  14. M. D. Majewska, N. L. Harrison, R. D. Schwartz, J. L. Barker, and S. M. Paul, “Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor,” Science, vol. 232, no. 4753, pp. 1004–1007, 1986. View at Publisher · View at Google Scholar · View at Scopus
  15. A. L. Morrow, P. D. Suzdak, and S. M. Paul, “Steroid hormone metabolites potentiate GABA receptor-mediated chloride ion flux with nanomolar potency,” European Journal of Pharmacology, vol. 142, no. 3, pp. 483–485, 1987. View at Publisher · View at Google Scholar · View at Scopus
  16. C. Corpéchot, J. Young, M. Calvel et al., “Neurosteroids: 3α-hydroxy-5α-pregnan-20-one and its precursors in the brain, plasma, and steroidogenic glands of male and female rats,” Endocrinology, vol. 133, no. 3, pp. 1003–1009, 1993. View at Publisher · View at Google Scholar · View at Scopus
  17. J. M. Jez and T. M. Penning, “The aldo-keto reductase (AKR) superfamily: an update,” Chemico-Biological Interactions, vol. 130-132, pp. 499–525, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. R. C. Agís-Balboa, G. Pinna, A. Zhubi et al., “Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 39, pp. 14602–14607, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. R. J. Cabrera, C. Bregonzio, M. Laconi, and A. Mampel, “Allopregnanolone increase in striatal N-methyl-D-aspartic acid evoked [3H]dopamine release is estrogen and progesterone dependent,” Cellular and Molecular Neurobiology, vol. 22, no. 4, pp. 445–454, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. M. R. Laconi, C. Chavez, J. C. Cavicchia et al., “Allopregnanolone alters the luteinizing hormone, prolactin, and progesterone serum levels interfering with the regression and apoptosis in rat corpus luteum,” Hormone and Metabolic Research, vol. 44, no. 8, pp. 632–638, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Casas, S. García, R. Cabrera, F. Nanfaro, C. Escudero, and R. Yunes, “Progesterone prevents depression-like behavior in a model of Parkinson's disease induced by 6-hydroxydopamine in male rats,” Pharmacology Biochemistry and Behavior, vol. 99, no. 4, pp. 614–618, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. C. Larramendy, I. R. E. Taravini, M. D. Saborido, J. E. Ferrario, M. G. Murer, and O. S. Gershanik, “Cabergoline and pramipexole fail to modify already established dyskinesias in an animal model of parkinsonism,” Behavioural Brain Research, vol. 194, no. 1, pp. 44–51, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. F. Nanfaro, R. Cabrera, V. Bazzocchini, M. Laconi, and R. Yunes, “Pregnenolone sulfate infused in lateral septum of male rats impairs novel object recognition memory,” Pharmacological Reports, vol. 62, no. 2, pp. 265–272, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. S. L. González, F. Labombarda, M. C. González Deniselle, R. Guennoun, M. Schumacher, and A. F. De Nicola, “Progesterone up-regulates neuronal brain-derived neurotrophic factor expression in the injured spinal cord,” Neuroscience, vol. 125, no. 3, pp. 605–614, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. J. P. Frankel, A. J. Lees, P. A. Kempster, and G. M. Stern, “Subcutaneous apomorphine in the treatment of Parkinson's disease,” Journal of Neurology Neurosurgery and Psychiatry, vol. 53, no. 2, pp. 96–101, 1990. View at Publisher · View at Google Scholar · View at Scopus
  26. C. R. Estrella, C. Bregonzio, and R. J. Cabrera, “Differential responses in central dopaminergic activity induced by apomorphine in IPL nude rat,” Behavioural Brain Research, vol. 133, no. 2, pp. 143–148, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. C. Escudero, S. Casas, F. Giuliani et al., “Allopregnanolone prevents memory impairment: effect on mRNA expression and enzymatic activity of hippocampal 3-α hydroxysteroid oxide-reductase,” Brain Research Bulletin, vol. 87, no. 2-3, pp. 280–285, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. J. Randall, “Protein measurement with the Folin phenol reagent,” The Journal of Biological Chemistry, vol. 193, no. 1, pp. 265–275, 1951. View at Google Scholar · View at Scopus
  29. F. Blandini, M.-T. Armentero, and E. Martignoni, “The 6-hydroxydopamine model: news from the past,” Parkinsonism and Related Disorders, vol. 14, no. 2, pp. S124–S129, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Schumacher, R. Guennoun, D. G. Stein, and A. F. de Nicola, “Progesterone: therapeutic opportunities for neuroprotection and myelin repair,” Pharmacology & Therapeutics, vol. 116, no. 1, pp. 77–106, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. R. Guennoun, D. Meffre, F. Labombarda et al., “The membrane-associated progesterone-binding protein 25-Dx: expression, cellular localization and up-regulation after brain and spinal cord injuries,” Brain Research Reviews, vol. 57, no. 2, pp. 493–505, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. F. Labombarda, S. Gonzalez, M. C. G. Deniselle et al., “Progesterone increases the expression of myelin basic protein and the number of cells showing NG2 immunostaining in the lesioned spinal cord,” Journal of Neurotrauma, vol. 23, no. 2, pp. 181–192, 2006. View at Publisher · View at Google Scholar · View at Scopus