Cortex Fraxini (Qingpi) Protects Rat Pheochromocytoma Cells against 6-Hydroxydopamine-Induced Apoptosis

Figure 7

QP water extract exerted neuroprotective effect on 6-OHDA treated PC12 cells through inhibiting ERK pathway. (a) Pretreatment of PD98059 for 2 h prevented 6-OHDA-induced cell apoptosis in a concentration-dependent manner. Data were expressed as means SEM of three separate experiments, with versus control and and versus 6-OHDA alone group. (b) The increase of phospho-ERK and phospho-MEK caused by 6-OHDA (500 M) at 15 min was reversed by pretreatment with QP water extract (0.5 mg/mL, 2 h). (c) The band from three independent experiments were quantified by densitometry and shown as group. Calculated as fold of control, data were expressed as means ± SEM of three separate experiments, versus control and and versus 6-OHDA alone group.

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