Four Copies of SNCA Responsible for Autosomal Dominant Parkinson’s Disease in Two Italian Siblings

Figure 3

Schematic representation of the multiplication described on chromosome 4, consisting of a 351 Kb triplication of a locus containing SNCA and 6 exons of MMRN1 gene (90.500.031 Mb to 90.851.296 Mb) and a duplication of 1,29 Mb of a genomic region flanking the triplication, involving TIGD2, GPRIN3, SNCA, and MMRN1 and from exon 1 to exon 3 of CCSER1 (90.013.153 Mb to 91.310.633 Mb). Scale is expressed in Megabases (Mb).