The Diagnostic and Differential Diagnosis Utility of Cerebrospinal Fluid α-Synuclein Levels in Parkinson’s Disease: A Meta-Analysis

Table 1

Summary of studies included in the systematic review.

Author

Year

Detection method

PD

Control

MSA

DLB

PSA

References

CSF

CSF

CSF

CSF

CSF

α-syn (ng/mL)

α-syn (ng/mL)

α-syn (ng/mL)

α-syn (ng/mL)

α-syn (ng/mL)

Parnetti

2014

ELISA

44

22.15 (11.86–38.64)

25

36.5 (25.8–49.6)

[15]

Parnetti

2014

ELISA

71

22.00 (13.50–38.60)

45

39.67 (27.72–64.60)

[16]

Mondello

2014

ELISA

52

0.84 (0.69–1.01)

22

1.31 (0.94–1.5)

34

0.75 (0.64–1.06)

32

0.98 (0.79–1.2)

[17]

Van Dijk

2014

TR-FRET immunoassay

53

1.48 ± 0.41

50

1.70 ± 0.47

[18]

Mollenhauer

2013

ELISA

78

1.339 ± 0.236

48

1.504 ± 0.337

[19]

Aerts

2012

ELISA

58

26.0 (20.5–32.5)

57

25.0 (18.0–42.0)

47

25 (17–32)

24

24 (23–34)

[20]

Wang

2012

Luminex

83

0.389 ± 0.137

51

0.520 ± 0.130

14

0.330 ± 0.120

30

0.42 ± 0.186

[21]

109

0.399 ± 0.137

71

0.487 ± 0.181

20

0.319 ± 0.114

22

0.419 ± 0.120

Shi

2011

Luminex

126

0.38 ± 0.10

137

0.49 ± 0.17

20

0.30 ± 0.09

[22]

Parnetti

2011

ELISA

38

43.1 ± 47

32

68.9 ± 71

32

18.1 ± 16

[23]

Mollenhauer

2011

ELISA

273

1.34 ± 0.81

23

2.22 ± 1.31

15

1.11 ± 0.45

66

1.32 ± 0.62

8

1.78 ± 0.91

[24]

51

1.19 ± 0.81

76

1.73 ± 1.83

29

1.24 ± 0.99

55

1.42 ± 1.26

Hong

2010

Luminex

80

0.36 ± 0.10

91

0.47 ± 0.16

[25]

Öhrfelt

2009

ELISA

15

0.417 (0.246–0.522)

55

0.395 (0.298–0.452)

15

0.334 (0.220–0.406)

[26]