Table 2: AUC estimates calculated in ROC analyses and ROC characteristics at optimal cut-offs.

AUC (95% CI) valueCut-offSensitivity (95% CI)Specificity (95% CI)PPVNPV

ACE-R
 PD-NC versus PD-MCI0.78 (0.66–0.90)<0.00188.50.68 (0.50–0.81)0.91 (0.69–0.98)0.930.63
 PD-MCI versus PD-D0.78 (0.63–0.93)0.00782.50.70 (0.35–0.92)0.73 (0.56–0.86)0.410.90
ACE-R AO
 PD-NC versus PD-MCI0.64 (0.50–0.78)0.07717.50.51 (0.35–0.68)0.73 (0.50–0.88)0.760.47
 PD-MCI versus PD-D0.92 (0.77–1.00)<0.00115.50.90 (0.54–0.99)0.97 (0.84–1.00)0.900.97
ACE-R M
 PD-NC versus PD-MCI0.68 (0.55–0.82)0.02022.50.76 (0.58–0.88)0.50 (0.29–0.71)0.720.55
 PD-MCI versus PD-D0.71 (0.54–0.88)0.04320.50.90 (0.54–0.99)0.46 (0.30–0.63)0.310.94
ACE-R F
 PD-NC versus PD-MCI0.75 (0.61–0.88)0.00211.50.70 (0.53–0.84)0.73 (0.50–0.88)0.810.59
 PD-MCI versus PD-D0.62 (0.42–0.82)0.2648.50.50 (0.20–0.80)0.76 (0.58–0.88)0.360.85
ACE-R L
 PD-NC versus PD-MCI0.62 (0.47–0.76)0.14124.50.35 (0.21–0.53)0.91 (0.69–0.98)0.870.45
 PD-MCI versus PD-D0.56 (0.34–0.77)0.58523.50.40 (0.14–0.73)0.84 (0.67–0.93)0.400.84
ACE-R VA
 PD-NC versus PD-MCI0.63 (0.48–0.77)0.11015.50.62 (0.45–0.77)0.64 (0.41–0.82)0.740.50
 PD-MCI versus PD-D0.75 (0.58–0.93)0.01514.50.60 (0.27–0.86)0.78 (0.61–0.90)0.430.88

ACE-R: Addenbrooke’s Cognitive Examination, global score.
PD-NC: subjects with Parkinson’s disease with normal control.
PD-MCI: subjects with Parkinson’s disease with mild cognitive impairment.
PD-D: subjects with Parkinson’s disease with dementia.
ACE-R AO: Addenbrooke’s Cognitive Examination, domain attention and orientation.
ACE-R M: Addenbrooke’s Cognitive Examination, domain memory.
ACE-R F: Addenbrooke’s Cognitive Examination, domain verbal fluency.
ACE-R L: Addenbrooke’s Cognitive Examination, domain language.
ACE-R VA: Addenbrooke’s Cognitive Examination, domain visual spatial abilities.