Addenbrooke’s Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson’s Disease
Table 2
AUC estimates calculated in ROC analyses and ROC characteristics at optimal cut-offs.
AUC (95% CI)
value
Cut-off
Sensitivity (95% CI)
Specificity (95% CI)
PPV
NPV
ACE-R
PD-NC versus PD-MCI
0.78 (0.66–0.90)
<0.001
88.5
0.68 (0.50–0.81)
0.91 (0.69–0.98)
0.93
0.63
PD-MCI versus PD-D
0.78 (0.63–0.93)
0.007
82.5
0.70 (0.35–0.92)
0.73 (0.56–0.86)
0.41
0.90
ACE-R AO
PD-NC versus PD-MCI
0.64 (0.50–0.78)
0.077
17.5
0.51 (0.35–0.68)
0.73 (0.50–0.88)
0.76
0.47
PD-MCI versus PD-D
0.92 (0.77–1.00)
<0.001
15.5
0.90 (0.54–0.99)
0.97 (0.84–1.00)
0.90
0.97
ACE-R M
PD-NC versus PD-MCI
0.68 (0.55–0.82)
0.020
22.5
0.76 (0.58–0.88)
0.50 (0.29–0.71)
0.72
0.55
PD-MCI versus PD-D
0.71 (0.54–0.88)
0.043
20.5
0.90 (0.54–0.99)
0.46 (0.30–0.63)
0.31
0.94
ACE-R F
PD-NC versus PD-MCI
0.75 (0.61–0.88)
0.002
11.5
0.70 (0.53–0.84)
0.73 (0.50–0.88)
0.81
0.59
PD-MCI versus PD-D
0.62 (0.42–0.82)
0.264
8.5
0.50 (0.20–0.80)
0.76 (0.58–0.88)
0.36
0.85
ACE-R L
PD-NC versus PD-MCI
0.62 (0.47–0.76)
0.141
24.5
0.35 (0.21–0.53)
0.91 (0.69–0.98)
0.87
0.45
PD-MCI versus PD-D
0.56 (0.34–0.77)
0.585
23.5
0.40 (0.14–0.73)
0.84 (0.67–0.93)
0.40
0.84
ACE-R VA
PD-NC versus PD-MCI
0.63 (0.48–0.77)
0.110
15.5
0.62 (0.45–0.77)
0.64 (0.41–0.82)
0.74
0.50
PD-MCI versus PD-D
0.75 (0.58–0.93)
0.015
14.5
0.60 (0.27–0.86)
0.78 (0.61–0.90)
0.43
0.88
ACE-R: Addenbrooke’s Cognitive Examination, global score. PD-NC: subjects with Parkinson’s disease with normal control. PD-MCI: subjects with Parkinson’s disease with mild cognitive impairment. PD-D: subjects with Parkinson’s disease with dementia. ACE-R AO: Addenbrooke’s Cognitive Examination, domain attention and orientation. ACE-R M: Addenbrooke’s Cognitive Examination, domain memory. ACE-R F: Addenbrooke’s Cognitive Examination, domain verbal fluency. ACE-R L: Addenbrooke’s Cognitive Examination, domain language. ACE-R VA: Addenbrooke’s Cognitive Examination, domain visual spatial abilities.
