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Parkinson’s Disease
Volume 2015, Article ID 734746, 10 pages
Review Article

The Role of α-Synuclein and LRRK2 in Tau Phosphorylation

Department of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Sagamihara 2520373, Japan

Received 25 December 2014; Revised 2 April 2015; Accepted 2 April 2015

Academic Editor: E. K. Tan

Copyright © 2015 Fumitaka Kawakami and Takafumi Ichikawa. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


There is now a considerable body of experimental evidence that Parkinson’s disease arises through physiological interaction of causative molecules, leading to tau pathology. In this review, we discuss the physiological role of α-synuclein and LRRK2 in the abnormal phosphorylation of tau. In addition, as recent reports have indicated that heat shock proteins- (HSPs-) inducing drugs can help to ameliorate neurodegenerative diseases associated with tau pathology, we also discuss therapeutic strategies for PD focusing on inhibition of α-synuclein- and LRRK2-associated tau phosphorylation by HSPs.