Enhanced Neuroprotective Effects of Coadministration of Tetrandrine with Glutathione in Preclinical Model of Parkinson’s Disease

Figure 3

Effects on the tyrosine hydroxylase (TH) gene expression (a) and TH-positive neurons in the striatum of lesion sides (b). The expression of TH mRNA was examined by Reverse Transcriptase Polymerase Chain Reaction (RT-PCR). GAPDH served as an internal control. TH DNA quantification was obtained by densitometric analysis of the DNA band area. The TH-immunopositive neuronal cell survival was examined using immunohistochemical staining. Statistical histogram of the number of surviving TH-positive neurons represents the average of 20 brain slices from each group. Each bar represents mean ± standard deviation (SD) for six animals per group. , , comparison among different groups after drug treatment.

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