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Parkinson’s Disease
Volume 2016, Article ID 1279042, 19 pages
http://dx.doi.org/10.1155/2016/1279042
Review Article

Marijuana Compounds: A Nonconventional Approach to Parkinson’s Disease Therapy

Touro College of Pharmacy, 230 West 125th Street, Room 530, New York, NY 10027, USA

Received 8 June 2016; Revised 29 September 2016; Accepted 10 October 2016

Academic Editor: Jan Aasly

Copyright © 2016 Mariana Babayeva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Parkinson’s disease (PD), a neurodegenerative disorder, is the second most common neurological illness in United States. Neurologically, it is characterized by the selective degeneration of a unique population of cells, the nigrostriatal dopamine neurons. The current treatment is symptomatic and mainly involves replacement of dopamine deficiency. This therapy improves only motor symptoms of Parkinson’s disease and is associated with a number of adverse effects including dyskinesia. Therefore, there is unmet need for more comprehensive approach in the management of PD. Cannabis and related compounds have created significant research interest as a promising therapy in neurodegenerative and movement disorders. In this review we examine the potential benefits of medical marijuana and related compounds in the treatment of both motor and nonmotor symptoms as well as in slowing the progression of the disease. The potential for cannabis to enhance the quality of life of Parkinson’s patients is explored.