Altered Mitochondrial Respiration and Other Features of Mitochondrial Function in Parkin-Mutant Fibroblasts from Parkinson’s Disease Patients

Figure 5

Cell growth in patient-derived and control fibroblasts under basal (untreated) and CCCP-stressed conditions, as assessed by a CyQUANT assay. Boxplots depict grouped patients (P) and control (Ct) measurements for three experimental runs. Patient cells demonstrated higher cell growth under basal conditions (). A comparison of the magnitude of the effect of CCCP treatment within each fibroblast group (i.e., with and without cellular stress) demonstrated that the growth of patient-derived fibroblasts was significantly more suppressed by CCCP than the growth of control fibroblasts (). Fibroblasts from P1 were not available; results pertain to a comparison of P2 and P3 parkin-mutant fibroblast with the three controls. ; ; °, outlier; AU, arbitrary units.