Analysis of LRRK2, SNCA, and ITGA8 Gene Variants with Sporadic Parkinson’s Disease Susceptibility in Chinese Han Population
Table 3
Comparison of the genotype frequencies and the allele frequencies of LRRK2, SNCA, and ITGA8 polymorphisms.
Gene SNP
Group
Genotype %
Allele Min/Maj
MAF
MAF
OR (95% CI)
Power
CC
GC
GG
G/C
LRRK2
rs1491942
Patients total
291
49.9
240
41.2
52
8.9
0.84
344/822
0.30
0.36
1.884 (1.546–2.297)
2.60E − 10
1.00
Controls total
372
67.3
161
29.1
20
3.6
0.67
201/905
0.18
EOPD
65
49.6
54
41.2
12
9.2
0.84
78/184
1.924 (1.244–2.976)
3.03E − 03
Controls < 50 y
74
68.5
29
26.9
5
4.6
0.33
39/177
LOPD
226
50.0
186
41.2
40
8.8
0.82
266/638
1.874 (1.500–2.340)
2.46E − 08
Controls ≧ 50 y
298
67.0
132
29.7
15
3.4
0.87
162/728
GG
AG
AA
A/G
SNCA
rs2301134
Patients total
437
75.0
132
22.6
14
2.4
0.29
160/1006
0.14
0.20
1.237 (0.964–1.588)
9.43E – 02
0.42
Controls total
436
78.8
108
19.5
9
1.6
0.40
126/980
0.11
EOPD
97
74.0
32
24.4
2
1.5
1.00
36/226
1.561 (0.875–2.786)
1.29E − 01
Controls < 50 y
88
81.5
20
18.5
0
0.0
0.59
20/196
LOPD
340
75.2
100
22.1
12
2.7
0.16
124/780
1.176 (0.891–1.552)
2.52E − 01
Controls ≧ 50 y
348
78.2
88
19.8
9
2.0
0.25
106/784
AA
TA
TT
T/A
rs356221
Patients total
210
36.0
282
48.4
91
15.6
0.86
464/702
0.40
0.40
1.167 (1.985–1.382)
7.50E − 02
0.45
Controls total
231
41.8
244
44.1
78
14.1
0.31
400/706
0.36
EOPD
43
32.8
67
51.1
21
16.0
0.59
109/153
1.286 (0.887–1.864)
1.84E − 01
Controls < 50 y
46
42.6
47
43.5
15
13.9
0.67
77/139
LOPD
167
36.9
215
47.6
70
15.5
1.00
355/549
1.135 (0.938–1.374)
1.93E − 01
Controls ≧ 50 y
185
41.6
197
44.3
63
14.2
0.36
323/567
CC
GG
G/C
rs2301135
Patients total
544
93.3
39
6.7
<0.05
78/1088
0.07
0.19
7.857 (4.046–15.258)
9.12E − 13
1.00
Controls total
548
99.1
5
0.9
<0.05
10/1096
0.01
EOPD
129
98.5
2
1.5
<0.05
4/258
1.016 (1.000–1.031)
1.30E − 01
Controls < 50 y
108
100.0
0
0.0
<0.05
0/216
LOPD
415
91.8
37
8.2
<0.05
74/830
7.846 (4.026–15.288)
1.45E − 12
Controls ≧ 50 y
440
98.9
5
1.1
<0.05
10/880
TT
CT
C/T
ITGA8
rs7077361
Patients total
580
99.5
3
0.5
1.00
3/1163
0.00
0.00
2.85 (0.296–27.443)
6.25E − 01
0.34
Controls total
552
99.8
1
0.2
1.00
1/1105
0.00
EOPD
131
100.0
0
0.0
<0.05
0/262
0.995 (0.986–1.004)
4.52E − 01
Controls < 50 y
107
99.1
1
0.9
1.00
0/0
LOPD
449
99.3
3
0.7
1.00
3/449
1.003 (1.000–1.007)
2.50E − 01
Controls ≧ 50 y
445
100.0
0
0.0
<0.05
0/445
EOPD: early onset Parkinson’s disease; LOPD: late-onset Parkinson’s disease; : value obtained in the Hardy-Weinberg equilibrium (HWE) test; : significant value obtained in the case-control analysis; Min: minor; Maj: major; MAF: minor allele frequency; a: this study; b: 1000 genomes (Southern Han Chinese); c: power was calculated by Power and Sample Size Calculations version 3.1.2.
