Table 3: Comparison of the genotype frequencies and the allele frequencies of LRRK2, SNCA, and ITGA8 polymorphisms.

Gene SNPGroupGenotype %Allele Min/MajMAFMAFOR (95% CI)Power
CCGCGGG/C

LRRK2
rs1491942Patients total29149.9 24041.2528.90.84 344/8220.30 0.36 1.884 (1.546–2.297)2.60E − 101.00
Controls total 37267.3 16129.1203.60.67 201/9050.18
EOPD6549.6 5441.2129.20.84 78/1841.924 (1.244–2.976)3.03E − 03
Controls < 50 y7468.5 2926.954.60.33 39/177
LOPD22650.0 18641.2408.80.82 266/6381.874 (1.500–2.340)2.46E − 08
Controls ≧ 50 y29867.0 13229.7153.40.87 162/728

GGAGAAA/G

SNCA
rs2301134Patients total43775.0 132 22.6142.4 0.29 160/10060.14 0.20 1.237 (0.964–1.588)9.43E – 020.42
Controls total43678.8 108 19.591.6 0.40 126/9800.11
EOPD9774.0 32 24.421.5 1.00 36/2261.561 (0.875–2.786)1.29E − 01
Controls < 50 y8881.5 20 18.500.0 0.59 20/196
LOPD34075.2 100 22.1122.7 0.16 124/7801.176 (0.891–1.552)2.52E − 01
Controls ≧ 50 y34878.2 88 19.892.0 0.25 106/784

AATATTT/A

rs356221Patients total21036.0 28248.49115.6 0.86 464/7020.40 0.40 1.167 (1.985–1.382)7.50E − 020.45
Controls total23141.8 24444.17814.1 0.31 400/7060.36
EOPD4332.8 6751.12116.0 0.59 109/1531.286 (0.887–1.864)1.84E − 01
Controls < 50 y4642.6 4743.51513.9 0.67 77/139
LOPD16736.9 21547.67015.5 1.00 355/5491.135 (0.938–1.374)1.93E − 01
Controls ≧ 50 y18541.6 19744.36314.2 0.36 323/567

CCGGG/C

rs2301135Patients total54493.3 39 6.7 <0.0578/10880.07 0.19 7.857 (4.046–15.258)9.12E − 131.00
Controls total54899.1 5 0.9 <0.0510/10960.01
EOPD12998.5 2 1.5 <0.054/2581.016 (1.000–1.031)1.30E − 01
Controls < 50 y108100.00 0.0 <0.050/216
LOPD41591.8 37 8.2 <0.0574/8307.846 (4.026–15.288)1.45E − 12
Controls ≧ 50 y44098.9 5 1.1 <0.0510/880

TTCTC/T

ITGA8
rs7077361Patients total58099.5 30.5 1.00 3/11630.00 0.00 2.85 (0.296–27.443)6.25E − 010.34
Controls total55299.8 10.2 1.00 1/11050.00
EOPD131100.000.0 <0.050/2620.995 (0.986–1.004)4.52E − 01
Controls < 50 y10799.1 10.9 1.00 0/0
LOPD44999.3 30.7 1.00 3/4491.003 (1.000–1.007)2.50E − 01
Controls ≧ 50 y445100.000.0 <0.050/445

EOPD: early onset Parkinson’s disease; LOPD: late-onset Parkinson’s disease; : value obtained in the Hardy-Weinberg equilibrium (HWE) test; : significant value obtained in the case-control analysis; Min: minor; Maj: major; MAF: minor allele frequency; a: this study; b: 1000 genomes (Southern Han Chinese); c: power was calculated by Power and Sample Size Calculations version 3.1.2.