5-HT_2A Receptor Binding in the Frontal Cortex of Parkinson’s Disease Patients and Alpha-Synuclein Overexpressing Mice: A Postmortem Study

Figure 1

Receptor binding analysis and alpha-synuclein levels in postmortem prefrontal cortex of Parkinson’s disease (PD) patients. (a) Binding assays with [³H] MDL100.907 comparing membrane suspensions from postmortem prefrontal cortex of Parkinson’s disease (PD) patients and controls show higher maximum binding levels () of the receptor in the PD group. (b) Western blot showing higher levels of alpha-synuclein proteins in the PD brains included in the binding assay. Control = normal controls; PD = Parkinson’s disease patients. Significant . Student’s -test with mean ± SEM.

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