Rotigotine Objectively Improves Sleep in Parkinson’s Disease: An Open-Label Pilot Study with Actigraphic Recording

Table 1

Scale results before (T0) and during (T1) rotigotine treatment.

Scale	T0	T1
UPDRS-III	26 (18–41)	22 (11–39)	0.018
H&Y	2 (2-2)	2 (2-2)	0.083
MMSE	28 (27–30)	30 (27–30)	0.121
PDSS-2	20 (16–30)	9 (4–20)	0.001
ESS	5 (4–6)	2 (3–7)	0.937
PDQ-39	34 (19–55)	29 (18–42)	0.016
BDI	7 (3–12)	6 (5–13)	0.977

UPDRS-III = Unified Parkinson’s Disease (PD) Rating Scale-part III; H&Y = Hoehn and Yahr Score; MMSE = Mini Mental State Examination; PDSS-2 = PD Sleep Scale-2; ESS = Epworth Sleep Scale; PDQ-39 = PD Questionnaire-39; BDI = Beck Depression Inventory. Data are expressed as medians and 25th–75th percentiles. = statistical significance .