Methyl-Arginine Profile of Brain from Aged PINK1-KO+A53T-SNCA Mice Suggests Altered Mitochondrial Biogenesis

Figure 3

Subcellular localization scheme of proteins with mono-methyl-arginine that show changed abundance. The locations are shown according to GeneCards database information and published literature; diagrams from Motifolio toolkits were used for drawing. Red boxes represent upregulation events; green ellipses were used for downregulations, in sizes proportional to fold changes. Apart from the nuclear envelope around DNA and a histone in the center of the picture, the rough endoplasmic reticulum with associated translating RNA is shown in the upper left corner, the Golgi apparatus on the left side, and the smooth endoplasmic reticulum in the lower left corner; cytoskeletal elements extend from the right side of the nucleus to the cell membranes, which form a neurite towards the right side and the plasma membrane of an adjacent cell is shown in the lower right corner. Arrows indicate nuclear export and import.