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Parkinson’s Disease
Volume 2016, Article ID 5042604, 7 pages
http://dx.doi.org/10.1155/2016/5042604
Research Article

A Case-Control Association Study of RANTES (-28C>G) Polymorphism as a Risk Factor for Parkinson’s Disease in Isparta, Turkey

1Department of Medical Biology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey
2Department of Neurology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey
3Department of Biochemistry, Faculty of Science, Süleyman Demirel University, Isparta, Turkey

Received 14 August 2016; Revised 10 November 2016; Accepted 21 November 2016

Academic Editor: Jan Aasly

Copyright © 2016 Nilufer Sahin-Calapoglu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Recent studies have revealed that inflammatory processes are involved in the pathogenesis of Parkinson’s disease (PD). Multiple lines of evidence have suggested that chemokines and their receptors are involved in several neurodegenerative disorders. We have examined whether genetic polymorphisms at the genes encoding chemokines IL-8 (-251A>T), MCP-1 (-2518A/G), and RANTES (-28C>G) and chemokine receptors CCR2 (V64I) and CCR5 (-Δ32) were associated with sporadic PD risk in Isparta, Turkey. Method. The pilot case-control association study included 30 PD patients and 60 control subjects, who were all genotyped with PCR-RFLP for the five polymorphisms. Their genotype and haplotype frequencies were compared statistically. Results. One SNP (-28C>G) in RANTES revealed a significant association with PD (P (allele) < 0.0001, p-trend = 0.0007). The risk allele (G) in the homozygous and dominant models (OR = 17.29 and 32.10, 95% CI = 0.86–347.24 and 1.74–591.937, resp.) suggests additional PD risk. The haplotype TGCAN from the IL-8 (-251A>T), MCP-1 (-2518A>G), RANTES (-28C>G), CCR-2 (V64I), and CCR-5 (-Δ32) has protective effect (OR = 0.08 [CI = 0.01–0.63], ). Conclusions. Our data are the first indication of the role of RANTES (-28C>G) in PD risk.