Essential Oils May Lead α-Synuclein towards Toxic Fibrils Formation

Figure 1

Effects of essential oils on the fibrillation of α-Syn assessing with ThT fluorescence assay at 482 nm wavelength. (a) α-Syn (70 µM) was incubated at 37°C, pH 7.4, for 24 hours either (1) alone or in the presence of 1% (v/v) of (2) Ferula gummosa, (3) Eucalyptus globulus, (4) Myrtus communis (Myrtle), (5) Satureja hortensis, (6) Rosmarinus officinalis (Rosemary), (7) Mentha spicata (Spearmint), (8) Mentha piperita (Peppermint), (9) Cuminum cyminum (Cumin), (10) Artemisia dracunculus (Tarragon), (11) Citrus sinensis (Orange), (12) Citrus limonum (Lemon), (13) Thymus vulgaris (Thyme), (14) Lavandula officinalis (Lavender), (15) Mentha pulegium (Pennyroyal), and (16) Foeniculum vulgare (Fennel). (b) α-Syn (70 µM) was incubated as same as (a) in the presence of different concentrations of Myrtus communis. Each value represents the mean ± SD (). (one-way ANOVA) indicated the samples are significantly different from the control.

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