Ophthalmologic Baseline Characteristics and 2-Year Ophthalmologic Safety Profile of Pramipexole IR Compared with Ropinirole IR in Patients with Early Parkinson’s Disease
Table 7
Statistically significant () multivariate predictors of 2-year change in ophthalmologic parameters and ERG amplitudes (log10 [ERG amplitude] difference from baseline to 2 years). Longitudinal models were developed for all eyes as described in Section 3.
Parameter
Predictor
Effect estimate
95% CI
P value
2-year change in IOP
Baseline IOP
−0.6763
−0.7682 to −0.5845
<0.00001
2-year change in log10 oscillatory potential (OP)
Age
−0.00452
−0.00760 to −0.00144
0.00423
Baseline OP
−0.6236
−0.7558 to −0.4915
<0.00001
2-year change in log10 cone flicker response
Baseline cone flicker response
−0.6382
−0.7327 to −0.5437
<0.00001
Male versus female
−0.06067
−0.1080 to −0.01337
0.01220
2-year change in log10 a-wave single flash cone response
Baseline a-wave single flash cone response
−0.8217
−0.9050 to −0.7384
<0.00001
2-year change in log10 a-wave rod cone mixed response
Baseline a-wave rod cone mixed response
−0.6440
−0.7471 to −0.5408
<0.00001
2-year change in log10 b-wave rod cone mixed response
Baseline b-wave rod cone mixed response
−0.7409
−0.8399 to −0.6420
<0.00001
2-year change in log10 b-wave single flash cone response
Baseline b-wave single flash cone response
−0.6523
−0.7358 to −0.5688
<0.00001
2-year change in implicit time b-wave rod cone mixed response
Baseline implicit time b-wave rod cone mixed response
−0.8527
−0.9409 to −0.7646
<0.00001
Baseline UPDRS
0.04867
0.01477 to 0.08258
0.00512
2-year change in Roth error score
Baseline Roth error score
−0.4791
−0.5489 to −0.4094
<0.00001
Male versus female
20.6491
3.0181 to 38.2802
0.02194
No covariates significantly predicted 2-year change in spheroid. CI: confidence interval; IOP: intraocular pressure; UPDRS: Unified Parkinson’s Disease Rating Scale.
