Research Article

Using Tractography to Distinguish SWEDD from Parkinson’s Disease Patients Based on Connectivity

Table 3

Identified connections with significant group-wise differences. Significantly different connections are reported in terms of connectivity values and corrected values. Connectivity values are reported as mean ± standard deviation (SD). Bold text shows identified connections with significant differences (corrected ) between PD and SWEDD.

Group-wise differences
ConnectionNumber of fibers (mean ± SD)Corrected value
PDSWEDD

(a) Cortico-cortical connectionL_precentral-L_posteriorcingulate4.6 ± 8.231.56 ± 2.890.028
L_paracentral-L_superiorfrontal1.18 ± 1.673.21 ± 6.290.039
L_paracentral-L_posteriorcingulate8.72 ± 8.323.48 ± 4.35<0.001
L_posteriorcingulate-L_superiorfrontal11.7 ± 8.966.27 ± 6.230.003
L_parsorbitalis-R_superiorfrontal0.65 ± 3.332.18 ± 4.720.046
R_paracentral-L_paracentral0.65 ± 2.022.59 ± 4.50.014
R_paracentral-R_posteriorcingulate37.7 ± 23.4717.8 ± 23.3<0.001
R_precentral-R_posteriorcingulate13.1 ± 16.755.54 ± 14.30.034
R_posteriorcingulate-R_superiorfrontal43.67 ± 27.5419.94 ± 21.7<0.001
R_posteriorcingulate-R_superiorparietal10.45 ± 17.273.00 ±6.780.005
R_rostralmiddlefrontal-R_inferiorparietal1.42 ± 3.200.29 ± 1.170.045

(b) Cortico-subcortical connection L_pallidum-L_frontalpole0.77 ± 1.512.83 ± 6.400.045
L_pallidum-L_postcentral5.52 ± 9.1716.08 ± 26.30.012
L_putamen-L_precentral14.5 ± 8.9524.86 ± 24.480.013
L_putamen-L_rostralmiddlefrontal34.87 ± 30.8621.83 ± 21.340.035
L_caudate-L_rostralmiddlefrontal37.5 ± 41.415.59 ± 24.660.027
L_thalamusproper-L_rostralmiddlefrontal7.27 ± 9.753.27 ± 5.020.007
R_pallidum-R_superiorfrontal1.50 ± 2.764.57 ± 7.970.022

(c) Subcortical connection L_caudate-L_putamen2.28 ± 3.345.59 ± 7.580.009
R_putamen-R_pallidum2.28 ± 2.334.51 ± 3.980.002
Brainstem-L_putamen3.80 ± 5.717.78 ± 10.960.046
Brainstem-L_caudate2.00 ± 4.294.51 ± 6.460.048
Brainstem-R_thalamusproper31.48 ± 18.7242.08 ± 23.130.029