Neuroprotective Effects of Salidroside in the MPTP Mouse Model of Parkinson’s Disease: Involvement of the PI3K/Akt/GSK3β Pathway

Figure 1

Sal improved behavior disorders in the MPTP-induced PD mouse model in pole tests and open field tests. Mice were pretreated with a sham solution or Sal (15 or 45 mg/kg). (a) Time spent to completely turn downward (T-turn). (b) Time spent getting from the top of the pole to the floor (T-LA). (c) Locomotion frequency. (d) Time spent immobile. Each column represents the mean ± SEM (). and compared with the control group; and compared with the MPTP group.

(a)

(b)

(c)

(d)