A Randomized Controlled Trial of Chinese Medicine on Nonmotor Symptoms in Parkinson’s Disease
Table 3
Result of hierarchical approach.
Parameter
Week 16
Week 32
Week 38
JLT
Placebo
JLT
Placebo
JLT
Placebo
Total score of NMSS
−3.13 ± 29.49
5.75 ± 22.67
−2.27 ± 32.90
11.78 ± 28.93
0.48 ± 34.01
12.18 ± 26.08
Mean difference: −8.87
Mean difference: −14.05
Mean difference: −11.70
95% CI: −18.78 to 1.04
95% CI: −25.71 to −2.39
95% CI: −23.12 to −0.28
p value = 0.079
p value = 0.019
p value = 0.045
NMSS D3 total mood/cognition
−1.68 ± 12.12
0.93 ± 7.76
−3.54 ± 14.38
3.13 ± 9.36
−0.66 ± 15.02
3.18 ± 10.38
Mean difference: −2.61
Mean difference: −6.66
Mean difference: −3.84
95% CI: −6.43 to 1.22
95% CI: −11.23 to −2.10
95% CI: −8.71 to 1.02
p value = 0.181
p value = 0.005
p value = 0.120
NMSS D4 total perceptual/hallucinations
−0.64 ± 3.28
0.09 ± 0.59
−0.88 ± 4.17
0.71 ± 3.04
−0.86 ± 4.52
0.22 ± 1.76
Mean difference: −0.73
Mean difference: −1.58
Mean difference: −1.08
95% CI: −1.62 to 0.16
95% CI: −2.96 to −0.21
95% CI: −2.37 to 0.22
p value = 0.105
p value = 0.024
p value = 0.103
NMSS D6 Q21 constipation
−1.02 ± 3.89
1.47 ± 2.71
−1.25 ± 3.46
1.55 ± 3.40
−0.43 ± 3.68
1.75 ± 3.54
Mean difference: −2.49
Mean difference: −2.80
Mean difference: −2.17
95% CI: −3.75 to −1.23
95% CI: −4.09 to −1.50
95% CI: −3.53 to −0.82
p value < 0.001
p value < 0.001
p value = 0.002
p value was comparing the score changes at different time points between JLT group and placebo group by independent sample t-tests; values are given as mean ± S.D. Values in JLT group and placebo group are the score changed in the same group between different time points and baseline (score at different time points minus score at the baseline).
