Table 3: Result of hierarchical approach.

ParameterWeek 16Week 32Week 38
JLTPlaceboJLTPlaceboJLTPlacebo

Total score of NMSS−3.13 ± 29.495.75 ± 22.67−2.27 ± 32.9011.78 ± 28.930.48 ± 34.0112.18 ± 26.08
Mean difference: −8.87Mean difference: −14.05Mean difference: −11.70
95% CI: −18.78 to 1.0495% CI: −25.71 to −2.3995% CI: −23.12 to −0.28
p value = 0.079p value = 0.019p value = 0.045

NMSS D3 total
mood/cognition
−1.68 ± 12.120.93 ± 7.76−3.54 ± 14.383.13 ± 9.36−0.66 ± 15.023.18 ± 10.38
Mean difference: −2.61Mean difference: −6.66Mean difference: −3.84
95% CI: −6.43 to 1.2295% CI: −11.23 to −2.1095% CI: −8.71 to 1.02
p value = 0.181p value = 0.005p value = 0.120

NMSS D4 total
perceptual/hallucinations
−0.64 ± 3.280.09 ± 0.59−0.88 ± 4.170.71 ± 3.04−0.86 ± 4.520.22 ± 1.76
Mean difference: −0.73Mean difference: −1.58Mean difference: −1.08
95% CI: −1.62 to 0.1695% CI: −2.96 to −0.2195% CI: −2.37 to 0.22
p value = 0.105p value = 0.024p value = 0.103

NMSS D6 Q21
constipation
−1.02 ± 3.891.47 ± 2.71−1.25 ± 3.461.55 ± 3.40−0.43 ± 3.681.75 ± 3.54
Mean difference: −2.49Mean difference: −2.80Mean difference: −2.17
95% CI: −3.75 to −1.2395% CI: −4.09 to −1.5095% CI: −3.53 to −0.82
p value < 0.001p value < 0.001p value = 0.002

p value was comparing the score changes at different time points between JLT group and placebo group by independent sample t-tests; values are given as mean ± S.D. Values in JLT group and placebo group are the score changed in the same group between different time points and baseline (score at different time points minus score at the baseline).