Research Article

Programming for Stimulation-Induced Transient Nonmotor Psychiatric Symptoms after Bilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson’s Disease

Table 2

Clinical manifestations of STPS.

Number Description of episodeRelationship with medication Duration
TimesChief complaints and symptomsYMRSInterval between episode and operationTime of occurrence

(1)1Inexplicable euphoria (sense of floating)22Postoperative 1 month (newly activated)Day 1 after hospital dischargeMed-on 1.5 h2 h
2Inexplicable euphoria (sense of floating)Day 2 after hospital dischargeMed-on 1 h2.5 h

(2)1WailnonePostoperative 18 monthsDuring programmingMED+
ON
20 min

(3)1Hallucination (cloud-like light and shadow)nonePostoperative 2 monthsFirst night after hospital dischargeMed-onAbout 20 min
2Hallucination (cloud-like light and shadow) Second morning after programmingMed-on30 min

(4)1Hypomania (hard to restrain anger)30Postoperative 17 monthsDuring programmingMed-off10 min until adjustment of parameter
2Hypomania (sense of anger)28During programmingMed-off10 min until adjustment of parameter

(5)1Wail (induced by ordinary conversation)nonePostoperative 1 month (newly activated)During programmingMed-off5 min until adjustment of parameter
2Wail (induced by ordinary conversation)During programmingMed-off7 min
3Wail (induced by talking about the past)During programmingMed-on5 min

(6)1Hypomania (losing temper to wife)33Postoperative 26 monthsAt home, after programmingMed-onImproved after 10 min
2Hypomania (kicking roadside cars)At home, after programmingMed-on2 min, improved 1 min after deactivation

(7)1Inexplicable euphoria (laughing foolishly)20Postoperative 3 months (during programming)During programming1 h after intake10 h
2Inexplicable euphoria (laughing foolishly)During programming1.5 h after intake3 min

(8)1Hypomania (lost temper and smashed objects)34Postoperative 3 months (during programming)The 2nd day after hospital dischargeMed-on2 h
2Hypomania (flight of ideas and fidgeting)The 2nd day after getting homeMed-on2 h

(9)1Hypomania (emotional and quarreling)34Postoperative 14 monthsDay 6 after hospital discharge; 20 min after raising the voltage of 0.5 V with programming by patientsMed-on 1.5h1.5 h. Family members restored the stimulation parameter originally set by doctors

(10)1Abnormal sense of spatial orientation (unaware of his location when out of clinic)nonePostoperative 3.5 months (during programming)During programmingMed-off10 min, returned clinic for readjustment of parameters
2Abnormal sense of spatial orientationDuring programmingMed-off15 min, improved 2 min after parameter adjustment

(11)1Hypomania (shouting and fidgeting)29Postoperative 2.5 months (during programming)In the car on his way home after programmingMed-on1.5 h, improved after readjustment of parameters in the clinic