Research Article
Festination Correlates with SNCA Polymorphism in Chinese Patients with Parkinson’s Disease
Table 1
Characteristics of Han Chinese patients with Parkinson’s disease in the presence or absence of festination.
| | Variable | Festination | No festination | |
| | Males | 78 (63.9) | 75 (55.1) | 0.151 | | Mean age, yr | 64.8 ± 9.2 | 59.3 ± 11.9 | 0.000 | | <60 | 36 (29.5) | 59 (43.4) | 0.021 | | ≥60 | 86 (7.05) | 77 (56.6) | | | Mean age at onset, yr | 58.9 ± 10.2 | 55.9 ± 11.9 | 0.033 | | <55 | 44 (36.1) | 54 (39.7) | 0.548 | | ≥55 | 78 (63.9) | 82 (60.3) | | | Disease duration ≥ 5 yr | 63 (51.6) | 28 (20.6) | 0.000 | | Onset symptoms | | | 0.129 | | Tremor | 63 (51.6) | 83 (61.0) | | | Akinetic-rigid | 59 (48.4) | 53 (39.0) | | Hoehn and Yahr stage ≤ 2
| 38 (31.1) | 82 (60.3) | 0.000 | | rs11931074 | | | | | Genotype frequencies | | 0.015 | | GG | 24 (19.7) | 16 (11.8) | | | GT | 65 (53.3) | 61 (44.9) | | | TT | 33 (27.0) | 59 (43.4) | | | MAF (G) | 113 (46.3) | 93 (34.2) | 0.005 | | Dominant model (GG + GT) | 89 (73.0) | 77 (56.6) | 0.006 | | Recessive model (GG) | 24 (19.7) | 16 (11.8) | 0.080 | | rs894278 | | | | | Genotype frequencies | | 0.003 | | TT | 61 (50.0) | 40 (29.4) | | | GT | 51 (41.8) | 78 (57.4) | | | GG | 10 (8.2) | 18 (13.2) | | | MAF (G) | 71 (29.1) | 114 (41.9) | 0.002 | | Dominant model (TT+GT) | 112 (91.8) | 118 (86.8) | 0.194 | | Recessive model (TT) | 61 (50.0) | 40 (29.4) | 0.001 |
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Results are shown as mean ± SD or (%).
MAF: minor allele frequency.
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