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Parkinson’s Disease
Volume 2017, Article ID 3659784, 11 pages
https://doi.org/10.1155/2017/3659784
Research Article

Correlation of Visuospatial Ability and EEG Slowing in Patients with Parkinson’s Disease

1Division of Molecular and Cognitive Neuroscience, Neuropsychology and Behavioural Neurology Unit, University of Basel, Basel, Switzerland
2Department of Neurology, Hospital of the University of Basel, Petersgraben 4, 4031 Basel, Switzerland

Correspondence should be addressed to Pasquale Calabrese; hc.sabinu@eserbalac.elauqsap

Received 10 October 2016; Accepted 5 February 2017; Published 28 February 2017

Academic Editor: Ivan Bodis-Wollner

Copyright © 2017 Dominique Eichelberger et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Visuospatial dysfunction is among the first cognitive symptoms in Parkinson’s disease (PD) and is often predictive for PD-dementia. Furthermore, cognitive status in PD-patients correlates with quantitative EEG. This cross-sectional study aimed to investigate the correlation between EEG slowing and visuospatial ability in nondemented PD-patients. Methods. Fifty-seven nondemented PD-patients (17 females/40 males) were evaluated with a comprehensive neuropsychological test battery and a high-resolution 256-channel EEG was recorded. A median split was performed for each cognitive test dividing the patients sample into either a normal or lower performance group. The electrodes were split into five areas: frontal, central, temporal, parietal, and occipital. A linear mixed effects model (LME) was used for correlational analyses and to control for confounding factors. Results. Subsequently, for the lower performance, LME analysis showed a significant positive correlation between ROCF score and parietal alpha/theta ratio (, ) and occipital alpha/theta ratio (, ). No correlations were found in the group of patients with normal visuospatial abilities. Conclusion. We conclude that a reduction of the parietal alpha/theta ratio is related to visuospatial impairments in PD-patients. These findings indicate that visuospatial impairment in PD-patients could be influenced by parietal dysfunction.