Genetic Variations and mRNA Expression of NRF2 in Parkinson’s Disease

Figure 1

rs35652124 genotype and age of onset do not correlate with NRF2 mRNA expression. NRF2 mRNA expression in EBV transfected human lymphocytes. Values were normalized to GAPDH mRNA and to a reference sample consisting of cDNA from all control individuals; groups were compared using a -test (a) or one-way ANOVA (b) analysis. Error bars: standard error of mean. In (a) mRNA expression of all subjects was divided into two groups depending on their genotype for the promoter SNPs rs35652124. WT: subjects wild type for rs35652124 and rs35652124; subjects heterozygous () and homozygous () for rs35652124, . In (b) mRNA levels are analyzed according to disease status; LO: late onset PD; EO: early onset PD; .

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(b)