Genetic Variations and mRNA Expression of NRF2 in Parkinson’s Disease

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr class="thead"><td class="align_left">rs35652124</td><td class="align_center">Controls% (<svg height="6.1673pt" id="M35" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -5.96091 6.6501 6.1673" width="6.6501pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M495 86L479 114C446 82 419 66 409 66C401 66 401 72 406 97C420 166 436 231 453 297C489 435 454 448 428 448C406 448 384 439 354 422C305 394 222 327 161 247H159L183 345C200 415 194 448 173 448C143 448 82 410 23 351L38 325C64 349 95 371 105 371C111 371 116 365 109 336L25 -4L31 -12C50 -4 77 3 107 9C119 69 132 122 145 168C197 254 321 381 370 381C387 381 393 374 378 305L329 95C309 17 320 -12 345 -12C372 -12 430 19 495 86Z" id="g113-111"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="502" vert-adv-y="502"></glyph.data></g></svg>)</td><td class="align_center">LO PD% (<svg height="6.1673pt" id="M36" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -5.96091 6.6501 6.1673" width="6.6501pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M495 86L479 114C446 82 419 66 409 66C401 66 401 72 406 97C420 166 436 231 453 297C489 435 454 448 428 448C406 448 384 439 354 422C305 394 222 327 161 247H159L183 345C200 415 194 448 173 448C143 448 82 410 23 351L38 325C64 349 95 371 105 371C111 371 116 365 109 336L25 -4L31 -12C50 -4 77 3 107 9C119 69 132 122 145 168C197 254 321 381 370 381C387 381 393 374 378 305L329 95C309 17 320 -12 345 -12C372 -12 430 19 495 86Z" id="g113-111"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="502" vert-adv-y="502"></glyph.data></g></svg>)</td><td class="align_center">EO PD% (<svg height="6.1673pt" id="M37" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -5.96091 6.6501 6.1673" width="6.6501pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M495 86L479 114C446 82 419 66 409 66C401 66 401 72 406 97C420 166 436 231 453 297C489 435 454 448 428 448C406 448 384 439 354 422C305 394 222 327 161 247H159L183 345C200 415 194 448 173 448C143 448 82 410 23 351L38 325C64 349 95 371 105 371C111 371 116 365 109 336L25 -4L31 -12C50 -4 77 3 107 9C119 69 132 122 145 168C197 254 321 381 370 381C387 381 393 374 378 305L329 95C309 17 320 -12 345 -12C372 -12 430 19 495 86Z" id="g113-111"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="502" vert-adv-y="502"></glyph.data></g></svg>)</td><td class="align_center"><svg height="11.6412pt" id="M38" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.5914 13.593 11.6412" width="13.593pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M655 0V28C585 35 562 50 517 120C469 193 414 280 360 366C427 469 460 516 481 545C526 604 545 614 619 622V650H390V622C457 614 462 604 438 560C411 511 381 463 339 398C295 466 258 523 225 580C210 606 211 615 272 622V650H26V622C97 614 111 603 153 538C188 482 235 408 288 324C200 188 148 116 124 85C96 47 64 34 7 28V0H236V28C169 36 164 46 188 89C220 148 262 217 310 291C372 193 417 118 442 77C461 44 454 35 392 28V0H655Z" id="g113-151"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="654" vert-adv-y="654"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,8.515,-5.741)"><path d="M414 144C384 79 371 75 317 75H135L276 221C367 316 408 376 408 465C408 570 327 635 237 635C179 635 131 609 100 575L42 494L67 471C94 510 138 565 205 565C277 565 321 517 321 435C321 348 258 270 195 195C146 137 88 81 33 26V0H411C423 44 433 88 446 135L414 144Z" id="g50-51"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="487" vert-adv-y="487"></glyph.data></g></svg> (DF)</td><td class="align_center"><svg height="10.2124pt" id="M39" style="vertical-align:-3.42943pt" version="1.1" viewbox="-0.0498162 -6.78297 7.83752 10.2124" width="7.83752pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M570 304C570 398 525 448 414 448C385 448 343 445 312 434L329 511L321 518C297 504 262 482 244 460L233 411C195 397 159 381 128 358L135 332C160 347 189 360 224 373L111 -147C97 -210 84 -218 17 -231L13 -257L254 -247L259 -218L233 -216C183 -212 177 -202 189 -142L218 -1C238 -10 266 -12 283 -12C351 3 429 48 483 105C543 168 570 242 570 304ZM482 289C482 161 380 33 304 33C278 33 248 51 233 69L303 396C326 400 352 403 369 403C428 403 482 380 482 289Z" id="g113-113"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="593" vert-adv-y="593"></glyph.data></g></svg> value</td></tr><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr><td class="align_left">AA</td><td class="align_center">47.7 (230)</td><td class="align_center">41.9 (163)</td><td class="align_center">58.4 (52)</td><td class="align_center">14.19 (4)</td><td class="align_center">0.0067</td></tr><tr><td class="align_left">AG</td><td class="align_center">43.6 (210)</td><td class="align_center">49.4 (192)</td><td class="align_center">28.1 (25)</td><td class="align_center"> </td><td class="align_center"> </td></tr><tr><td class="align_left">GG</td><td class="align_center">8.7 (42)</td><td class="align_center">8.7 (34)</td><td class="align_center">13.5 (12)</td><td class="align_center"> </td><td class="align_center"> </td></tr><tr><td class="align_left">A</td><td class="align_center">69.5 (670)</td><td class="align_center">66.6 (518)</td><td class="align_center">72.5 (129)</td><td class="align_center">3.82 (2)</td><td class="align_center">0.15</td></tr><tr><td class="align_left">G</td><td class="align_center">30.5 (294)</td><td class="align_center">33.4 (260)</td><td class="align_center">27.5 (49)</td><td class="align_center"> </td><td class="align_center"> </td></tr><tr class="table-tr"><td colspan="6"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><svg height="6.1673pt" id="M40" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -5.96091 6.6501 6.1673" width="6.6501pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M495 86L479 114C446 82 419 66 409 66C401 66 401 72 406 97C420 166 436 231 453 297C489 435 454 448 428 448C406 448 384 439 354 422C305 394 222 327 161 247H159L183 345C200 415 194 448 173 448C143 448 82 410 23 351L38 325C64 349 95 371 105 371C111 371 116 365 109 336L25 -4L31 -12C50 -4 77 3 107 9C119 69 132 122 145 168C197 254 321 381 370 381C387 381 393 374 378 305L329 95C309 17 320 -12 345 -12C372 -12 430 19 495 86Z" id="g113-111"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="502" vert-adv-y="502"></glyph.data></g></svg>: number of individuals; PD: Parkinson’s disease; LO: late onset; EO: early onset; <svg height="11.6412pt" id="M41" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.5914 13.593 11.6412" width="13.593pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M655 0V28C585 35 562 50 517 120C469 193 414 280 360 366C427 469 460 516 481 545C526 604 545 614 619 622V650H390V622C457 614 462 604 438 560C411 511 381 463 339 398C295 466 258 523 225 580C210 606 211 615 272 622V650H26V622C97 614 111 603 153 538C188 482 235 408 288 324C200 188 148 116 124 85C96 47 64 34 7 28V0H236V28C169 36 164 46 188 89C220 148 262 217 310 291C372 193 417 118 442 77C461 44 454 35 392 28V0H655Z" id="g113-151"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="654" vert-adv-y="654"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,8.515,-5.741)"><path d="M414 144C384 79 371 75 317 75H135L276 221C367 316 408 376 408 465C408 570 327 635 237 635C179 635 131 609 100 575L42 494L67 471C94 510 138 565 205 565C277 565 321 517 321 435C321 348 258 270 195 195C146 137 88 81 33 26V0H411C423 44 433 88 446 135L414 144Z" id="g50-51"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="487" vert-adv-y="487"></glyph.data></g></svg>: chi square; DF: degrees of freedom.<br/></td></tr></table>

Results from age stratified genotype and allele analysis for rs35652124.

Parkinson’s Disease

tab3

Table 3

Table 3: Genetic Variations and mRNA Expression of NRF2 in Parkinson’s Disease 