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Parkinson’s Disease
Volume 2017, Article ID 4047392, 8 pages
https://doi.org/10.1155/2017/4047392
Research Article

Consensus on the Definition of Advanced Parkinson’s Disease: A Neurologists-Based Delphi Study (CEPA Study)

1Department of Neurology, Clínica Universidad de Navarra, Universidad de Navarra, Pamplona, Spain
2Department of Neurology, Movement Disorders Unit, Hospital de la Santa Creu i Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona, Universitat Oberta de Catalunya (UOC), Barcelona, Spain
3Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
4Area of Applied Research, National Center of Epidemiology, Carlos III Institute of Health, Madrid, Spain
5Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain
6Neurology Service, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain

Correspondence should be addressed to Maria-Rosario Luquin; se.vanu@niuqulr

Received 23 September 2016; Revised 23 December 2016; Accepted 5 January 2017; Published 23 January 2017

Academic Editor: Hélio Teive

Copyright © 2017 Maria-Rosario Luquin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. M. de Lau and M. M. Breteler, “Epidemiology of Parkinson's disease,” Lancet Neurology, vol. 5, no. 6, pp. 525–535, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. R. L. Nussbaum and C. E. Ellis, “Alzheimer's disease and Parkinson's disease,” The New England Journal of Medicine, vol. 348, no. 14, pp. 1356–1364, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. S. M. Calne, “The psychosocial impact of late-stage Parkinson's disease,” The Journal of Neuroscience Nursing, vol. 35, no. 6, pp. 306–313, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Coelho and J. J. Ferreira, “Late-stage Parkinson disease,” Nature Reviews Neurology, vol. 8, no. 8, pp. 435–442, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Weintraub, C. L. Comella, and S. Horn, “Parkinson's disease—Part 3: neuropsychiatric symptoms,” The American Journal of Managed Care, vol. 14, supplement 2, pp. S59–S69, 2008. View at Google Scholar · View at Scopus
  6. P. J. García-Ruiz and M. R. Luquin, “Limits of conventional oral and transdermal medication in Parkinson's disease,” Revista de Neurología, vol. 55, supplement 1, pp. S3–S6, 2012. View at Google Scholar · View at Scopus
  7. C. G. Goetz, G. T. Stebbins, and L. M. Blasucci, “Differential progression of motor impairment in levodopa-treated Parkinson's disease,” Movement Disorders, vol. 15, no. 3, pp. 479–484, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. C. Hinnell, C. S. Hurt, S. Landau et al., “Nonmotor versus motor symptoms: how much do they matter to health status in Parkinson's disease?” Movement Disorders, vol. 27, no. 2, pp. 236–241, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. S. W. Pedersen, J. Clausen, and M. M. Gregerslund, “Practical guidance on how to handle levodopa/carbidopa intestinal gel therapy of advanced PD in a movement disorder clinic,” The Open Neurology Journal, vol. 6, no. 1, pp. 37–50, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. C. Okoli and S. D. Pawlowski, “The Delphi method as a research tool: an example, design considerations and applications,” Information & Management, vol. 42, no. 1, pp. 15–29, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. G. J. Skulmoski, F. T. Hartman, and J. Krahn, “The Delphi method for graduate research,” Journal of Information Technology Education, vol. 6, pp. 1–21, 2007. View at Google Scholar
  12. C. Cook, J.-M. Brismée, R. Fleming, and P. S. Sizer Jr., “Identifiers suggestive of clinical cervical spine instability: a Delphi study of physical therapists,” Physical Therapy, vol. 85, no. 9, pp. 895–906, 2005. View at Google Scholar · View at Scopus
  13. J. Kulisevsky, M. R. Luquin, J. M. Arbelo et al., “Advanced Parkinson's disease: clinical characteristics and treatment (part 1),” Neurologia, vol. 28, no. 8, pp. 503–521, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. M. P. Pérez-Campanero, Cómo Detectar las Necesidades de Intervención Socioeducativa, Editorial Narcea, Madrid, Spain, 1991.
  15. J. McDonnell, A. Meijler, J. P. Kahan, S. J. Bernstein, and H. Rigter, “Panellist consistency in the assessment of medical appropriateness,” Health Policy, vol. 37, no. 3, pp. 139–152, 1996. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Martínez-Horta, J. Pagonabarraga, R. Fernández De Bobadilla, C. García-Sanchez, and J. Kulisevsky, “Apathy in Parkinson's disease: more than just executive dysfunction,” Journal of the International Neuropsychological Society, vol. 19, no. 5, pp. 571–582, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. P. A. Kempster, S. S. O'Sullivan, J. L. Holton, T. Revesz, and A. J. Lees, “Relationships between age and late progression of Parkinson's disease: a clinico-pathological study,” Brain, vol. 133, no. 6, pp. 1755–1762, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Coelho, M. J. Marti, C. Sampaio et al., “Dementia and severity of parkinsonism determines the handicap of patients in late-stage Parkinson's disease: the Barcelona-Lisbon cohort,” European Journal of Neurology, vol. 22, no. 2, pp. 305–312, 2015. View at Publisher · View at Google Scholar · View at Scopus
  19. B. R. Bloem, J. M. Hausdorff, J. E. Visser, and N. Giladi, “Falls and freezing of Gait in Parkinson's disease: a review of two interconnected, episodic phenomena,” Movement Disorders, vol. 19, no. 8, pp. 871–884, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Diamond and J. Jankovic, “Treatment of advanced Parkinson's disease,” Expert Review of Neurotherapeutics, vol. 6, no. 8, pp. 1181–1197, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. B. Pillon, B. Dubois, G. Cusimano, A.-M. Bonnet, F. Lhermitte, and Y. Agid, “Does cognitive impairment in Parkinson's disease result from non-dopaminergic lesions?” Journal of Neurology Neurosurgery & Psychiatry, vol. 52, no. 2, pp. 201–206, 1989. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Kulisevsky, J. Pagonbarraga, B. Pascual-Sedano, C. García-Sánchez, and A. Gironell, “Prevalence and correlates of neuropsychiatric symptoms in Parkinson's disease without dementia,” Movement Disorders, vol. 23, no. 13, pp. 1889–1896, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Pagonabarraga and J. Kulisevsky, “Cognitive impairment and dementia in Parkinson's disease,” Neurobiology of Disease, vol. 46, no. 3, pp. 590–596, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. P. Martinez-Martin, A. H. V. Schapira, F. Stocchi et al., “Prevalence of nonmotor symptoms in Parkinson's disease in an international setting; study using nonmotor symptoms questionnaire in 545 patients,” Movement Disorders, vol. 22, no. 11, pp. 1623–1629, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Antonini, P. Barone, R. Marconi et al., “The progression of non-motor symptoms in Parkinson's disease and their contribution to motor disability and quality of life,” Journal of Neurology, vol. 259, no. 12, pp. 2621–2631, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. K. R. Chaudhuri, J. M. Rojo, A. H. V. Schapira et al., “A proposal for a comprehensive grading of Parkinson's disease severity combining motor and non-motor assessments: meeting an unmet need,” PLoS ONE, vol. 8, Article ID e57221, 2013. View at Publisher · View at Google Scholar
  27. M. A. Hely, J. G. L. Morris, W. G. J. Reid, and R. Trafficante, “Sydney Multicenter Study of Parkinson's disease: non-L-dopa-responsive problems dominate at 15 years,” Movement Disorders, vol. 20, no. 2, pp. 190–199, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Kulisevsky, R. Fernández de Bobadilla, J. Pagonabarraga et al., “Measuring functional impact of cognitive impairment: validation of the Parkinson's disease cognitive functional rating scale,” Parkinsonism & Related Disorders, vol. 19, no. 9, pp. 812–817, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. M. A. Lee, W. M. Prentice, A. J. Hildreth, and R. W. Walker, “Measuring symptom load in Idiopathic Parkinson's disease,” Parkinsonism & Related Disorders, vol. 13, no. 5, pp. 284–289, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. P. Martinez-Martin, C. Rodriguez-Blazquez, M. M. Kurtis, and K. R. Chaudhuri, “The impact of non-motor symptoms on health-related quality of life of patients with Parkinson's disease,” Movement Disorders, vol. 26, no. 3, pp. 399–406, 2011. View at Publisher · View at Google Scholar · View at Scopus