Variant Region Alleles Studies with significant association with PD risk REP1 Promoter 259 bp/261 bp/263 bp [47 , 50 , 60 , 64 , 65 , 68 , 71 –73 , 75 , 77 , 79 , 81 ] (↑) [43 , 56 , 76 ] (↓) rs1372519 Promoter A/G [49 ] (↓) rs2301134 Promoter C/T [45 , 76 ] (↑) rs2301135 Promoter C/G [45 ] (↓) rs2619361 Promoter A/C [49 ] (↑) rs2619362 5′ region C/T [49 ] (↑) rs2619363 5′ region G/T [49 , 77 ] (↑) rs2619364 5′ region A/G [66 , 77 ] (↑) rs2583988 5′ region C/T [49 , 56 , 61 , 77 ] (↑) rs2119787 Intron A/G [65 ] (↓) rs2197120 Intron A/G [56 ] (↓) rs2572324 Intron C/T [49 , 60 , 64 , 65 ] (↑) rs2583959 Intron C/G [49 , 64 ] (↑) rs2736990 Intron T/C [27 , 28 , 41 , 47 , 49 , 52 , 55 , 60 ] (↑) [40 ] (↓) rs2737020 Intron C/T [76 ] (↓) rs2737029 Intron C/T [56 , 65 , 80 ] (↑) rs2737033 Intron A/G [46 ] (↑) rs356164 Intron C/G [76 ] (↓) rs356168 Intron A/G [64 , 80 ] (↑) rs356186 Intron A/G [56 , 60 , 76 ] (↓) rs356203 Intron A/G [27 , 80 ] (↑) rs356204 Intron A/G [80 ] (↑) rs3822086 Intron C/T [37 ] (↓) rs3857057 Intron A/G [33 ] (↑) rs3857059 Intron A/G [29 , 80 ] (↑) rs6848726 Intron C/T [80 ] (↓) rs7684318 Intron C/T [27 , 66 ] (↑) rs7689942 Intron C/T [33 ] (↑) rs894278 Intron G/T [35 , 36 ] (↑) rs1372520 Intron C/T [47 , 49 ] (↑) [60 ] (↓) rs10018362 Intron C/T [33 ] (↑) rs2737012 Intron C/T [49 ] (↑) rs3756063 Intron C/G [36 ] (↑) rs3775423 Intron C/T [48 , 60 , 64 ] (↑) rs356221 3′ region A/T [45 , 48 , 77 ] (↑) rs356165 3′ region A/G [28 , 50 , 51 , 54 , 69 , 73 , 76 , 77 , 80 ] (↑) rs356182 3′ region A/G [32 ] (↑) rs356218 3′ region A/G [47 , 49 , 60 ] (↑) rs356219 3′ region A/G [28 , 42 , 44 , 46 , 52 , 53 , 59 , 61 –63 , 65 , 73 , 78 , 80 ] (↑) rs356220 3′ region C/T [27 , 28 , 30 , 33 , 52 , 55 , 80 ] (↑) [40 ] (↓) rs356225 3′ region C/T [33 ] (↑) rs181489 3′ region C/T [61 , 76 , 77 ] (↑) rs11931074 3′ region G/T [30 , 31 , 34 , 39 , 55 , 57 , 61 ] (↑) [37 , 45 ] (↓)