The Single Nucleotide Polymorphism rs1014290 of the<i> SLC2A9</i> Gene Is Associated with Uric Acid Metabolism in Parkinson’s Disease

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td class="align_left" rowspan="2">Group</td><td class="align_center" rowspan="2">Number</td><td class="align_center" colspan="2">UA (<i>µ</i>mol/L)</td><td class="align_center" rowspan="2"><span style="width: 8.15071ptpx;"><svg height="8.68572pt" id="M51" style="vertical-align:-0.0498209pt" version="1.1" viewbox="-0.0498162 -8.6359 8.15071 8.68572" width="8.15071pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z" id="g113-81"></path></g></svg></span></td></tr><tr class="thead"><td class="align_center">TT + CT</td><td class="align_center">CC</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td class="align_left">PD</td><td class="align_center">220</td><td class="align_center"><span style="width: 75.891ptpx;"><svg height="8.69875pt" id="M52" style="vertical-align:-0.3499298pt" version="1.1" viewbox="-0.0498162 -8.34882 75.891 8.69875" width="75.891pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M285 378C315 398 338 416 353 432C373 451 384 474 384 503C384 579 325 635 236 635H235C182 635 136 610 108 579L65 516L85 496C110 533 150 575 205 575C258 575 300 543 300 481C300 407 232 369 141 339L147 310C163 315 188 321 211 321C268 321 338 284 338 192C338 94 288 40 217 40C160 40 119 68 93 91C85 98 77 97 69 91C60 84 47 71 46 58C44 46 48 35 62 22C75 10 116 -12 162 -12C234 -12 424 62 424 224C424 297 373 359 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class="align_center">&lt;0.001</td></tr><tr><td class="align_center" colspan="2"><span style="width: 8.15071ptpx;"><svg height="8.68572pt" id="M56" style="vertical-align:-0.0498209pt" version="1.1" viewbox="-0.0498162 -8.6359 8.15071 8.68572" width="8.15071pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z" id="g113-81"></path></g></svg></span></td><td class="align_center">0.004</td><td class="align_center">0.031</td><td class="align_center"> </td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><svg height="8.68572pt" id="M57" style="vertical-align:-0.0498209pt" version="1.1" viewbox="-0.0498162 -8.6359 8.15071 8.68572" width="8.15071pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z" id="g113-81"></path></g></svg> values compare individuals with different genotypes within the same group; UA, uric acid.<br/></td></tr></table>

Average serum uric acid levels in the PD and control groups. Individuals and PD patients carrying the CC genotype had lower uric acid levels as compared to those with the TT and CT genotypes.

Parkinson’s Disease

tab4

Table 4

Table 4: The Single Nucleotide Polymorphism rs1014290 of the<i> SLC2A9</i> Gene Is Associated with Uric Acid Metabolism in Parkinson’s Disease 

Parkinson’s Disease

The Single Nucleotide Polymorphism rs1014290 of the SLC2A9 Gene Is Associated with Uric Acid Metabolism in Parkinson’s Disease

Table 4