Ex Vivo and In Vivo Characterization of Interpolymeric Blend/Nanoenabled Gastroretentive Levodopa Delivery Systems

Table 6

Mean cerebrospinal fluid concentration after oral administration of Madopar HBS capsules, PXLNET,and IPB matrices.

Time (h)	Mean CSF concentration (ng/mL)
	Madopar HBS			PXLNET			IPB
	M-D	D-M	L-D	M-D	D-M	L-D	M-D	D-M	L-D
2.00	36.47	—	88.69	35.63	83.01	70.48	3.27	—	71.96
4.00	28.31	—	224.12	27.86	82.94	87.79	30.44	—	97.15

M-D, methyldopa; D-M, dopamine; and L-D, levodopa.