Twice-Daily versus Once-Daily Pramipexole Extended Release Dosage Regimens in Parkinson’s Disease

Table 2

Dose switches from conventional dopaminergic agonist to pramipexole ER.

Pramipexole IR pramipexole ER			Ropinirole pramipexole ER
Pramipexole IR daily dose, mg	Pramipexole ER, mg		Ropinirole daily dose, mg	Pramipexole ER, mg
	Once-daily	Twice-daily		Once-daily	Twice-daily
0.7 ≤ pramipexole < 0.8	0.75	0.375-0.375	3.0 ≤ ropinirole < 4.0	0.75	0.375-0.375
0.8 ≤ pramipexole < 1.1	1.125	0.75-0.375	4.0 ≤ ropinirole < 7.0	1.125	0.75-0.375
1.1 ≤ pramipexole < 1.6	1.5	0.75-0.75	7.0 ≤ ropinirole < 8.0	1.5	0.75-0.75
1.6 ≤ pramipexole < 1.9	1.875	1.125-0.75	8.0 ≤ ropinirole < 10.0	1.875	1.125-0.75
1.9 ≤ pramipexole < 2.3	2.25	1.125-1.125	10.0 ≤ ropinirole < 12.0	2.25	1.125-1.125
2.3 ≤ pramipexole < 2.7	2.625	1.5-1.125	12.0 ≤ ropinirole < 14.0	2.625	1.5-1.125
2.7 ≤ pramipexole < 3.1	3.0	1.5-1.5	14.0 ≤ ropinirole < 16.0	3.0	1.5-1.5
3.1 ≤ pramipexole < 3.4	3.375	1.875-1.5	16.0 ≤ ropinirole < 17.0	3.375	1.875-1.5
3.4 ≤ pramipexole < 3.8	3.75	1.875-1.875	17.0 ≤ ropinirole < 19.0	3.75	1.875-1.875
3.8 ≤ pramipexole < 4.2	4.125	2.25-1.875	19.0 ≤ ropinirole < 21.0	4.125	2.25-1.875
4.2 ≤ pramipexole < 4.6	4.5	2.25-2.25	21.0 ≤ ropinirole < 23.0	4.5	2.25-2.25
4.6 ≤ pramipexole < 4.9	4.875	2.625-2.25	23.0 ≤ ropinirole < 25.0	4.875	2.625-2.25

IR, immediate-release; ER, extended-release.