Research Article
Microarray Analysis of the Molecular Mechanism Involved in Parkinson’s Disease
Table 1
List of top 10 differentially expressed genes with higher degrees in protein-protein interaction network.
| Gene | Full name | Description | Degree |
| MAPK14 | Mitogen-activated protein kinase 14 | Down | 68 | ESR1 | Estrogen receptor 1 | Up | 54 | PTEN | Phosphatase and tensin homolog | Down | 52 | MTOR | Mechanistic target of rapamycin | Up | 40 | ATM | ATM serine/threonine kinase | Up | 35 | ICAM1 | Intercellular adhesion molecule 1 | Down | 33 | CD40 | CD40 molecule | Up | 32 | AURKA | Aurora kinase A | Down | 31 | PRKDC | Protein kinase, DNA-activated, catalytic polypeptide | Down | 29 | TK2 | Thymidine kinase 2, mitochondrial | Up | 29 |
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Degree was used for describing the importance of protein nodes in network. The higher the degree was, the more important the nodes were in network.
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