A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson’s Disease

Table 2

GBA-related phenotypes updated to our previous meta-analysis.

Phenotypes	Number of articles (total/updated)	Total number of GBA + PD	Total number of GBA − PD	OR or MD (95% CI) updated	value	Previous OR or MD (95% CI)
Family history^a	11/1	558	9330	1.65 (1.34, 2.02)	<0.00001	1.5 (1.18, 1.91)
AAO^b	17/4	622	11079	−3.61 (−5.04, −2.17)	<0.00001	−3.10 (−4.88, −1.32)
UPDRS-III^b	9/4	335	6100	2.17 (0.72, 3.62)	0.003	1.61 (−0.65, 3.87)
H-Y^b	11/3	275	3863	0.18 (0.00, 0.35)	0.05	0.06 (−0.06, 0.17)
Dementia^a	8/2	224	2696	2.44 (1.79, 3.33)	<0.00001	3.21 (1.97, 5.24)
Depression^#a	5	196	2825	1.47 (1.02, 2.13)	0.04	—
Orthostatic hypotension^#a	4	138	1913	1.24 (0.79, 1.94)	0.35	—
Motor fluctuation^#a	3	195	2894	0.9 (0.66, 1.24)	0.53	—
Wearing-off^#a	3	88	1226	1.68 (1.05, 2.69)	0.03	—
Freezing^#a	3	128	1688	1.14 (0.74, 1.77)	0.55	—

Abbreviations: phenotypes updated new publications; ^#phenotypes newly analyzed. PD, Parkinson’s disease; GBA + PD, PD with GBA mutations; GBA - PD, PD without GBA mutations; AAO, age at onset; UPSRS-III, the Part III of Unified Parkinson Disease Rating Scale; OR, odds ratio; MD, mean deviation; CI, confidence interval. Bold OR or MD, 95% CI, and values reflected statistically significance results; a, dichotomous variables reflected by OR (95% CI); b, continuous outcomes reflected by MD (95% CI).