Parkinson’s Disease / 2018 / Article / Tab 1

Research Article

The Association between LRRK2 G2385R and Phenotype of Parkinson’s Disease in Asian Population: A Meta-Analysis of Comparative Studies

Table 1

Characteristics of included publication.

ArticleCountryLRRK2 G2385RNumberFamily historySex (male)Disease durationAAO (n)AAO (EOPD)AAO (LOPD) (n)Initial symptomH-YUPDRS-IIIMotor symptomNonmotor symptomsLED (mg)Motor fluctuationDyskinesiaNOS score
TremorBradykinesiaPIRigidityTremorRigidityBradykinesiaPIGDMMSEDepression

An et al. [5]ChinaCarriers714052.75 ± 9.8442.96 ± 7.2358.40 ± 5.93372.16 ± 0.918
noncarriers52931456.32 ± 11.2640.81 ± 7.3561.07 ± 7.272632.33 ± 0.98

Cai et al. [10]ChinaCarriers49285.18 ± 2.5856.8 ± 10.741.6 ± 5.9161.3 ± 7.0434240182.47 ± 0.8921.4 ± 8.788
noncarriers4612754.92 ± 3.3658.6 ± 11.042.9 ± 5.563.2 ± 7.3329922491682.57 ± 0.9322.1 ± 8.35

Cao et al. [7]ChinaCarriers14058.57 ± 8.7157.1 ± 11.087571.7 ± 0.419.6 ± 5.137
noncarriers221131285.52 ± 4.8154.4 ± 13.413410264832.0 ± 0.820.5 ± 7.357

Cao et al. [16]ChinaCarriers25162.2 ± 0.85
noncarriers43282.4 ± 0.74

Chan et al. [17]Hong KongCarriers42.7 ± 2.3 (3)74.3 ± 4.9 (4)6
Chinanoncarriers38.3 ± 6.6 (34)69.2 ± 10.7 (44)

Di Fonzo et al. [18]TaiwanCarriers613413.4 ± 6.253.2 ± 12.58
Chinanoncarriers54732811.2 ± 6.055.0 ± 11.9

Farrer et al. [3]TaiwanCarriers346187.3 ± 5.454.9 ± 11.824323012457.6 ± 246.612138
Chinanoncarriers376202147.2 ± 4.658.0 ± 11.7258343365150444.6 ± 270.9122117

Funayama et al. [20]JapanCarriers54.0 ± 10.6 (50)42.5 ± 5.8 (17)59.9 ± 7.0 (33)7
noncarriers50.3 ± 14.9 (389)37.1 ± 9.4 (180)61.6 ± 7.8 (209)

Fung et al. [22]TaiwanCarriers2761.5 ± 11.32626277
Chinanoncarriers27861.9 ± 10.5252261269

Fu et al. [19]ChinaCarriers3782155 ± 11.72111137
noncarriers3655120155.0 ± 11.0220811626

Gao et al. [7]ChinaCarriers362214.1 ± 2.760.5 ± 10.4161627.2 ± 3.41366
noncarriers13910733.8 ± 3.258.2 ± 8.8557325.3 ± 4.0156

Hong et al. [21]KoreanCarriers2373.8 ± 3.119.8 ± 11.225.6 ± 4.457
noncarriers2761364.2 ± 3.323.6 ± 8.725.0 ± 4.056

Kim et al. [9]KoreanCarriers823555.3 ± 11.59
noncarriers84137354.7 ± 10.8

Sun et al. [6]ChinaCarriers76376.57 ± 4.2155.57 ± 8.782.15 ± 0.8324.55 ± 12.08294327.78 ± 2.6827553.67 ± 329.842747
noncarriers2251255.73 ± 3.5557.05 ± 8.922.08 ± 0.8126.52 ± 12.641406926.96 ± 2.9258467.71 ± 286.34508

Tan et al. [8]SingaporeCarriers3351659.0. ± 11.026.0 ± 11.0467.0 ± 275.075
noncarriers2901859.0 ± 10.027.0 ± 11.0537.0 ± 287.011

Zhou et al. [23]ChinaCarriers261.82 ± 0.587
noncarriers1761.76 ± 0.76