Parkinson’s Disease / 2018 / Article / Tab 2

Research Article

The Association between LRRK2 G2385R and Phenotype of Parkinson’s Disease in Asian Population: A Meta-Analysis of Comparative Studies

Table 2

Summarized results of the meta-analysis.

SubjectsEffect modelMD/OR (95% CI) valueStudy heterogeneity
Chi2dfI2 (%) value

Family historyFixed1.98 [1.16–3.39]0.015.424260.25
Gender (male)Fixed0.85 [0.70–1.02]0.086.091100.87
Disease durationFixed0.47 [0.01–0.93]0.048.166270.23
AAOFixed−0.06 [−0.15 to 0.03]0.1916.3211330.13
AAO (early-onset)Random2.43 [−0.55 to 5.42]0.1119.473850.0002
AAO (late-onset)Random−1.54 [−3.38 to 0.30]0.106.673550.08
Initial symptoms—tremorFixed1.05 [0.76–1.45]0.760.70300.87
Initial symptoms—rigidityFixed1.14 [0.70–1.86]0.600.61200.74
Initial symptoms—bradykinesiaFixed1.17 [0.76–1.79]0.480.61200.74
Initial symptoms—PIFixed0.97 [0.39–2.39]0.940.78200.68
H-YFixed−0.09 [−0.20 to 0.01]0.077.395320.19
UPDRS-IIIFixed−1.35 [−2.82 to 0.11]0.071.56400.82
Motor symptoms—tremorRandom0.88 [0.40–1.91]0.7410.413710.02
Motor symptoms—rigidityFixed1.59 [0.48–5.27]0.450.01100.94
Motor symptoms—bradykinesiaFixed0.43 [0.15–1.24]0.121.901470.17
Motor symptoms—PIGDRandom1.24 [0.48–3.23]0.6612.472840.002
MMSEFixed1.02 [0.43–1.62]0.00072.272120.32
DepressionFixed1.46 [0.90–2.37]0.130.39100.53
LEDFixed0.14 [−0.06 to 0.33]0.173.782470.15
Motor fluctuationRandom1.73 [0.99–3.01]0.057.522730.02
DyskinesiaRandom1.26 [0.63–2.54]0.528.264520.08