The Association between LRRK2 G2385R and Phenotype of Parkinson’s Disease in Asian Population: A Meta-Analysis of Comparative Studies

Table 2

Summarized results of the meta-analysis.

Subjects	Effect model	MD/OR (95% CI)	value	Study heterogeneity
				Chi^2	df	I^2 (%)	value
Family history	Fixed	1.98 [1.16–3.39]	0.01	5.42	4	26	0.25
Gender (male)	Fixed	0.85 [0.70–1.02]	0.08	6.09	11	0	0.87
Disease duration	Fixed	0.47 [0.01–0.93]	0.04	8.16	6	27	0.23
AAO	Fixed	−0.06 [−0.15 to 0.03]	0.19	16.32	11	33	0.13
AAO (early-onset)	Random	2.43 [−0.55 to 5.42]	0.11	19.47	3	85	0.0002
AAO (late-onset)	Random	−1.54 [−3.38 to 0.30]	0.10	6.67	3	55	0.08
Initial symptoms—tremor	Fixed	1.05 [0.76–1.45]	0.76	0.70	3	0	0.87
Initial symptoms—rigidity	Fixed	1.14 [0.70–1.86]	0.60	0.61	2	0	0.74
Initial symptoms—bradykinesia	Fixed	1.17 [0.76–1.79]	0.48	0.61	2	0	0.74
Initial symptoms—PI	Fixed	0.97 [0.39–2.39]	0.94	0.78	2	0	0.68
H-Y	Fixed	−0.09 [−0.20 to 0.01]	0.07	7.39	5	32	0.19
UPDRS-III	Fixed	−1.35 [−2.82 to 0.11]	0.07	1.56	4	0	0.82
Motor symptoms—tremor	Random	0.88 [0.40–1.91]	0.74	10.41	3	71	0.02
Motor symptoms—rigidity	Fixed	1.59 [0.48–5.27]	0.45	0.01	1	0	0.94
Motor symptoms—bradykinesia	Fixed	0.43 [0.15–1.24]	0.12	1.90	1	47	0.17
Motor symptoms—PIGD	Random	1.24 [0.48–3.23]	0.66	12.47	2	84	0.002
MMSE	Fixed	1.02 [0.43–1.62]	0.0007	2.27	2	12	0.32
Depression	Fixed	1.46 [0.90–2.37]	0.13	0.39	1	0	0.53
LED	Fixed	0.14 [−0.06 to 0.33]	0.17	3.78	2	47	0.15
Motor fluctuation	Random	1.73 [0.99–3.01]	0.05	7.52	2	73	0.02
Dyskinesia	Random	1.26 [0.63–2.54]	0.52	8.26	4	52	0.08