| Drug | Gene | Interaction types | Approved? | Administration | Approved use | PubMed ID |
| Citric acid | MDH2 | N/A | Yes | Oral administration | Anticoagulation | 10592235 | Folic acid | MTR | N/A | yes | Oral administration | Trophic nerve | | Hydroxocobalamin | MTR | Cofactor | Yes | Oral administration/intravenous drip | Neuroprotection | 18565, 1744096, 7599160, 3812589, 9587031 | L-glutamate | ASNS, GLUD1, GOT1 | N/A | Phase 3 | Oral administration | Neuroprotection | 17139284, 17016423, 8288265, 17139284, 17016423, 17444813 | Metformin hydrochloride | NDUFA10, NDUFA7, NDUFA9, NDUFB5, NDUFS1, NDUFV2 | Inhibitor | Yes | Oral administration | Hypoglycemic effect | | Methionine | MTR | Product | Yes | Oral administration | Liver protection | 17222188, 16618098, 17615995, 16788729, 17052662 | Niacinamide | LDHA | N/A | Yes | Oral administration | Cardiac disease, cognitive disorder | 10592235, 17139284, 17016423 | Pyridoxal phosphate | GOT1, SDS | Activator | Phase 2 | Oral administration | Dyskinesia | 11340119, 16925884, 12167474, 11888303, 11752352, 14596599, 15155761, 14646100, 16580895, 15689518 | Quercetin | ATP5B | N/A | Phase 1 | Oral administration | Pain | 10592235 | Serine | SDS | N/A | Phase 2 | Oral administration | Cognitive improvement | 4377655, 14688104, 17139284, 17016423, 500557 |
|
|