CLOCK 3111T/C Variant Correlates with Motor Fluctuation and Sleep Disorders in Chinese Patients with Parkinson’s Disease
Table 1
Demographic data and clinical profiles of carriers and noncarriers.
CLOCK 3111T/C carriers (TC + CC)
CLOCK 3111T/C noncarriers (TT)
value
n = 124
n = 522
Age (years)
62.35 ± 10.19
61.70 ± 10.13
0.515
Sex (%)
53 (42.7)
263 (50.4)
0.126
Onset age (years)
58.52 ± 10.33
58.02 ± 10.79
0.645
EOPD (%)
12 (9.7)
26 (5.0)
0.046a
Disease duration (years)
3.90 ± 3.18
3.74 ± 3.04
0.550
Family history (%)
7 (5.6)
31 (5.9)
0.987
Formal education (years)
9.47 ± 3.38
9.63 ± 3.65
0.657
Hoehn-Yahr stage
1.84 ± 0.78
1.74 ± 0.73
0.165
UPDRS II + III
41.81 ± 19.73
40.26 ± 19.04
0.417
Mean tremor score
4.27 ± 4.19
4.00 ± 3.79
0.476
Mean PIGD score
7.71 ± 5.26
8.02 ± 5.25
0.691
Motor fluctuation
1.93 ± 1.88
0.83 ± 1.41
0.000b
Dyskinesia
0.33 ± 0.94
0.25 ± 1.03
0.453
L-dopa therapy initial dosage (mg/day)
148.7 ± 38.86
154.6 ± 41.12
0.215
L-dopa therapy duration (year)
3.22 ± 2.57
2.95 ± 2.80
0.071
Good response to levodopa
107 (86.3)
474 (90.8)
0.133
MMSE
25.23 ± 3.51
25.37 ± 3.32
0.682
Sleep disorder (%)
48 (38.7)
138 (26.4)
0.007a
Depression
10.26 ± 3.67
8.88 ± 3.73
0.183
Orthostatic hypotension (%)
16 (12.9)
69 (13.2)
0.926
The χ2 square test was used to compare the categorical variables. Data are expressed as numbers with percentages in parentheses or as mean ± SE. UPDRS: Unified Parkinson’s Disease Rating Scale; MMSE: Mini-Mental State Examination; EOPD: early-onset PD; PIGD: postural instability and gait difficulty. a and b.
