Parkinson’s Disease

Research Article

Gastrointestinal Dysfunctions Are Associated with IL-10 Variants in Parkinson’s Disease

Table 1

Demographic data and clinical characteristics of PD patients in both IL-10 rs1800871 and rs1800872 carriers and noncarriers (numerical variables).


	Carriers		Noncarriers		p	SC
	N	X ± S	N	X ± S	p	SC

Age	177	62.64 ± 10.46	190	63.23 ± 9.49	NA	NA
UPDRS I	165	2.30 ± 1.97	174	2.32 ± 2.37	0.977	−0.002
UPDRS II	165	12.88 ± 6.49	174	13.78 ± 8.08	0.319	−0.054
UPDRS III	172	26.76 ± 14.70	178	29.26 ± 16.01	0.157	−0.075
H-Y	156	2.27 ± 0.93	161	2.40 ± 0.96	0.211	−0.070
LEDD	166	556.08 ± 281.23	178	517.52 ± 314.51	0.201	0.070
PDSS	67	106.39 ± 23.33	70	107.13 ± 27.26	0.657	−0.039
NMSS-D1	64	0.97 ± 2.03	68	0.79 ± 1.78	0.492	0.062
NMSS-D2	64	10.88 ± 6.67	68	9.79 ± 6.95	0.334	0.087
NMSS-D3	64	7.97 ± 9.78	68	7.71 ± 9.52	0.862	−0.016
NMSS-D4	64	1.61 ± 2.58	68	1.69 ± 3.23	0.818	0.020
NMSS-D5	64	3.25 ± 3.82	68	4.44 ± 4.68	0.235	−0.105
NMSS-D6	64	4.25 ± 4.58	68	6.07 ± 4.76	0.023	−0.198
NMSS-D7	64	6.55 ± 5.29	68	7.18 ± 6.02	0.649	−0.040
NMSS-D8	64	0.92 ± 3.05	68	0.53 ± 2.43	0.524	0.057
PDQ-39	64	36.33 ± 25.68	70	32.91 ± 23.39	0.376	0.079
CCI	177	0.12 ± 0.40	190	0.17 ± 0.50	0.259	−0.059

Abbreviations: UPDRS I, II, III, Unified Parkinson’s Disease Rating Scale part I, II, III; H-Y, Hoehn and Yahr Scale; LEDD, Levodopa equivalent daily dose; PDSS, Parkinson’s Disease Sleep Scale; NMSS, Nonmotor Symptoms Scale; NMSS-D1, NMSS-cardiovascular; NMSS-D2, NMSS-sleep/fatigue; NMSS-D3, NMSS-mood/apathy; NMSS-D4, NMSS-perception/hallucinations; NMSS-D5, NMSS-attention/memory; NMSS-D6, NMSS-gastrointestinal; NMSS-D7, NMSS-urinary; NMSS-D8, NMSS-sexual dysfunction; PDQ-39, the 39-item Parkinson’s Disease Questionnaire; CCI, Charlson Comorbidity Index. N represented the total number of carriers and noncarriers of both IL-10 rs1800871 and rs1800872 in PD patients. Numerical variable was presented as mean and standard deviation (X ± S). values <0.05 were considered of statistical significance and was shown in boldface text. SC, standardized coefficient; NA, not available.