Gastrointestinal Dysfunctions Are Associated with IL-10 Variants in Parkinson’s Disease

Table 2

Demographic data and clinical characteristics of PD patients in both IL-10 rs1800871 and rs1800872 carriers and noncarriers (categorical variables).

	Carriers		Noncarriers		p	OR	95% CI
	N	N (F)	N	N (F)
Gender, male	177	91(51.4%)	190	97(51.1%)	NA	NA	NA
WO	159	19(11.9%)	159	26(16.4%)	0.258	0.692	0.365–1.311
FOG	46	14(30.4%)	56	20(35.7%)	0.626	0.811	0.348–1.887
Cognitive impairment	96	26(27.1%)	96	25(26.0%)	0.497	1.263	0.644–2.478
Olfactory dysfunction	63	29(46.0%)	68	35(51.5%)	0.633	0.843	0.418–1.700
Depression	84	32(38.1%)	82	32(39.0%)	0.844	0.938	0.496–1.774
RBD	63	27(42.9%)	70	30(42.9%)	0.749	1.122	0.553–2.277
EDS	65	20(30.8%)	72	31(43.1%)	0.314	0.686	0.329–1.430

Abbreviations: WO, wearing-off phenomenon which was evaluated by 9-item Wearing-off Questionnaire (WOQ-9); FOG, freezing of gait which was assessed by the New Freezing of Gait Questionnaire (NFOG-Q); cognitive impairment which was assessed by mini mental state examination (MMSE); Olfactory dysfunction which was assessed by the Hyposmia Rating Scale (HRS); depression which was assessed by the Hamilton Depression Scale (HAMD); RBD, REM sleep behavior disorder which was assessed by REM Sleep Behavior Disorder Questionnaire-Hong Kong (RBDQ-HK); EDS, excessive daytime sleepiness which was assessed by the Epworth Sleepiness Scale (ESS). N represented the total number of carriers and noncarriers of both IL-10 rs1800871 and rs1800872 in PD patients. Categorical variable was presented as number of carriers or noncarriers and its relevant frequency separately [N (F)]. P value <0.05 was considered of statistical significance. OR, odds ratio; CI, confidence interval; NA, not available.