Zonisamide Enhances Motor Effects of Levodopa, Not of Apomorphine, in a Rat Model of Parkinson’s Disease

<div>Western blot analysis of the dopamine-denervated striatum in rats treated with levodopa plus zonisamide (<i>n</i> = 4) and levodopa only (<i>n</i> = 6). The raw data for dopamine decarboxylase (DDC) and vesicular monoamine transferase-2 (VMAT-2) (a). There were no significant differences in the levels of DDC (b) and VMAT-2 (c) relative to the levels of actin between the two groups. NS, not significant.</div>

Parkinson’s Disease

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Figure 5

Figure 5: Zonisamide Enhances Motor Effects of Levodopa, Not of Apomorphine, in a Rat Model of Parkinson’s Disease 