Parkinson’s Disease

Review Article

Meta-Analysis of the Relationship between the APOE Gene and the Onset of Parkinson’s Disease Dementia

Table 1

Data extraction table.
ResearcherTimeCountryExperimental group (PDD group)Control group (PDND group)Experimental groupControl groupPDD diagnostic criteriaDementia evaluation methodExperimental methodSample capacity (experimental group and control group ≥ 50)Patient sourceAverage ageLiterature quality
2/22/32/43/33/44/42/22/32/43/33/44/4ε4+ε4−ε4+ε4−
Koller et al. [21]1995America163291210623814116361744Calne criteriaDRSCase-control studyYesResearch centerPD67.4, PDD74.78
Harhangi et al. [22]2000Netherlands18179001425113110161665Calne criteriaDSMCohort studyNoCommunityPD75.8, PDD82.17
Wang et al. [30]2001China010640010354047436Diagnostic criteria of National Symposium on Extrapyramidal Diseases in 1984DSMCase-control studyNoHospitalPD66.13, PDD71.096
Zhou et al. [31]2004China01010312302461411729Diagnostic criteria of National Symposium on Extrapyramidal Diseases in 1984DSMCase-control studyNoHospital平均Averagely 67.46
Camicioli et al. [37]2005Canada            919316PathologyDSMCohort studyNoHospitalPD77.5, PDD78.17
Pankratz et al. [38]2006America            193162212UK Brain BankMMSECase-control studyNoCommunityAveragely 60.97
Troster et al. [39]2006America            9111131Calne criteriaDRSCase-control studyYesResearch centerAveragely 68.67
Blazquez et al. [40]2006Spain            62525220UK Brain BankMMSECase-control studyNoHospitalAveragely 71.17
Ma [23]2007China09248193117296161245719114UK Brain BankDSMCase-control studyNoHospitalPD68.38, PDD69.728
Jasinska-Myga et al. [32]2007Poland1113562431875625330683565UK Brain BankDSM, MMSECase-control studyYesHospitalPD61.7, PDD71.48
Tong [33]2008China0401330030521203171255UK Brain BankDSM, MMSECase-control studyYesHospitalPD70.35, PDD75.447
Ezquerra et al. [34]2008Spain071572010110101260226426112UK Brain BankPDD diagnostic criteriaCase-control studyNoHospitalPD56, PDD58.37
Williams-Gray et al. [41]2009America            8112365UK Brain BankDSM, MMSECohort studyYesCommunityUnknown7
Irwin et al. [4]2012America            4049438UK Brain BankDSMCase-control studyNoResearch centerPD80, PDD797
Wang [35]2014China180701710183116200187923134UK Brain BankPDD diagnostic criteriaCase-control studyNoHospitalPD65.20, PDD67.958
Mengel et al. [36]2016Germany0123342215569222812264692283UK Brain BankMDS-TFCCase-control studyYesResearch centerAveragely 66.76
Nicoletti et al. [42]2016Italy            13121212UK Brain BankMMSECase-control studyYesUnknownAveragely 64.78