Mediating Effect of Mutuality on Health-Related Quality of Life in Patients with Parkinson’s Disease

Table 3

Indirect and total effects of disease-related factors on PD patients’ health-related quality of life (bootstrap sample = 2000).

Effects	Path	Standardized path coefficient	95% CI bias-corrected percentile			value
Indirect effect with one mediator	ADL  ⟶  Pat. MS ⟶ PDQ8	−0.120	−0.300	—	0.014	0.079
	UPDRS III ⟶ Pat. MS ⟶ PDQ8	0.103	0.010	—	0.239	0.026
	NMS ⟶ Pat. MS ⟶ PDQ8	0.112	0.006	—	0.263	0.043
	IQCODE ⟶ Part. MS ⟶ Pat. MS	−0.199	−0.339	—	−0.057	0.011
Total effect	ADL ⟶ PDQ8	0.100	−0.115	—	0.351	0.335
	UPDRS III ⟶ PDQ8	0.126	−0.116	—	0.334	0.372
	NMS ⟶ PDQ8	0.552	0.344	—	0.735	0.001
	IQCODE ⟶ PD-pat. MS	−0.139	−0.343	—	0.157	0.295

Note: PD: Parkinson’s disease; ADL: activities of daily life (0 = independent; 1 = dependent); Pat. MS: PD patients’ mutuality scale; PDQ8: Parkinson’s disease questionnaire summary index; UPDRS III: unified Parkinson’s disease rating scale-part III; NMS: non-motor symptoms questionnaire; IQCODE: informant questionnaire on cognitive decline in the elderly; Part. MS: PD partners’ mutuality scale.