Dosing Patterns during Conversion to IPX066, Extended-Release Carbidopa-Levodopa (ER CD-LD), in Parkinson’s Disease with Motor Fluctuations

Table 1

ADVANCE-PD dose conversion from IR CD-LD to ER CD-LD

Total daily dose of levodopa in immediate-release carbidopa-levodopa	Recommended staring dosage of RYTARY
	Total daily dose of levodopa in RYTARY	RYTARY dosing regimen
400 mg to 549 mg	855 mg	3 capsules RYTARY 23.75 mg/95 mg taken TID^a
550 mg to 749 mg	1140 mg	4 capsules RYTARY 23.75 mg/95 mg taken TID^a
750 mg to 949 mg	1305 mg	3 capsules RYTARY 36.25 mg/145 mg taken TID^a
950 mg to 1249 mg	1755 mg	3 capsules RYTARY 48.75 mg/195 mg taken TID^a
Equal to or greater than 1250 mg	2340 mg or 2205 mg	4 capsules RYTARY 48.75 mg/195 mg taken TID^a or 3 capsules RYTARY 61.25 mg/245 mg taken TID^a

^aTID: three times a day.