Dosing Patterns during Conversion to IPX066, Extended-Release Carbidopa-Levodopa (ER CD-LD), in Parkinson’s Disease with Motor Fluctuations

Table 2

ASCEND-PD dose conversion from IR CD-LD + entacapone to ER CD-LD

Total daily dose of levodopa in immediate-release carbidopa-levodopa + entacapone	Recommended staring dosage of RYTARY
	Total daily dose of levodopa in RYTARY	RYTARY dosing regimen
400–500 mg	1140 mg	380 mg (4 capsules × 95 mg) taken TID^a
551–750 mg	1470 mg	490 mg (2 capsules × 245 mg) taken TID^a
751–950 mg	1755 mg	585 mg (3 capsules × 195 mg) taken TID^a
951–1250 mg	2205 mg	735 mg (3 capsules × 245 mg) taken TID^a
>1250 mg	2940 mg	980 mg (4 capsules × 245 mg) taken TID^a

^aAt 6-hour intervals during the subject’s waking day; TID: three times a day.