The Parkinson’s Disease Composite Scale Is Adequately Responsive to Acute Levodopa Challenge

Table 2

Average changes in MDS-UPDRS and PDCS motor scores during acute levodopa challenge.

	OFF state (points)	ON state (points)	Change (points)	Change (%)
MDS-UPDRS Part III	45.1 ± 15.3	33.2 ± 15.2	−11.9 ± 10.1	−27.0 ± 20.1
PDCS motor score	13.7 ± 6.2	10.1 ± 6.5	−3.6 ± 4.0	−28.7 ± 30.3

Any antiparkinsonian medication was discontinued at least 12 hours before the assessment. 60 minutes after a single dose of 200–400 mg immediate-release formulation of levodopa/benserazide or in the best ON state. Data are mean ± standard deviation. MDS-UPDRS = Movement Disorder Society-sponsored Unified Parkinson’s Disease Rating Scale; PDCS = Parkinson’s Disease Composite Scale.